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First human administration of mr04a3: A novel water-soluble nonbenzodiazepine sedative
J. Robert Sneyd
*
,
Ann E. Rigby-Jones
, Maurice Cross
, Hideharu Tominaga
, Satoshi Shimizu
, Takako Ohkura
, Karen Grimsehl
*
Corresponding author for this work
Faculty of Health
Peninsula Medical School, Universities of Exeter and Plymouth
Pharmaceutical Physician, Veeda Limited
Maruishi Pharmaceutical Co., Ltd.
University Hospitals Plymouth NHS Trust
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Medicine and Dentistry
Placebo
100%
Sedative Agent
100%
Nonbenzodiazepine
100%
Adverse Event
33%
Volunteer
33%
Hemodynamic
33%
Infusion
33%
Bispectral Index
33%
Arterial Pressure
33%
Central Nervous System
33%
Drug Megadose
33%
Upper Respiratory Tract Obstruction
33%
Ramsay Sedation Scale
33%
Benzodiazepine Receptor Stimulating Agent
33%
Pharmacology, Toxicology and Pharmaceutical Science
Nonbenzodiazepine
100%
Dose Concentration
100%
Placebo
75%
Adverse Event
25%
Benzodiazepine Receptor Stimulating Agent
25%
Upper Respiratory Tract Obstruction
25%