TY - JOUR
T1 - Exploring incidence and risk factors for persistent postoperative opioid use in adult surgical patients: a systematic review protocol
AU - Griffiths, Harry
AU - Kent, Bridie
AU - Martin, Daniel
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Objective:
The objective of this review is to determine the incidence of persistent postsurgical use of opioids in adult patients and the associated risk factors.
Introduction:
Surgery has been identified as an independent risk factor for unwarranted chronic opioid use, contributing to opioid-related harm in the community. Persistent opioid use after surgery is associated with morbidity and mortality from opioid-related adverse events, indicating a significant yet mitigable public health concern. There is substantial variation in the reported incidence and risk factors for postoperative opioid use, which require evaluation for future evidence-based risk-reduction strategies.
Inclusion criteria:
This review will include studies investigating the persistent use of opioids after 90 postoperative days in adult (≥18 y) patients undergoing surgery of any type, including patients with cancer pain. Selected evidence must report on opioid use prior to surgery. Analytical and descriptive observational studies, and experimental and quasi-experimental studies, published in the previous decade will be eligible for inclusion.
Methods:
The proposed study methods follow the JBI methodology for systematic reviews of prevalence and incidence. A systematic search will be conducted in PubMed, Embase, CINAHL, Cochrane Central, and Web of Science, and a search of gray literature will include Google Scholar and ClinicalTrials.gov. Study selection, critical appraisal, and data extraction will be performed by 2 independent reviewers aided by the relevant JBI systematic review tools. We aim to produce a narrative synthesis of results and conduct a meta-analysis where feasible, in addition to subgroup analyses of suitable populations. The results are intended to promote safe, evidence-based postoperative opioid prescribing when considering risk factors for persistent postoperative opioid use.
Systematic review registration number:
PROSPERO CRD42022320691
AB - Objective:
The objective of this review is to determine the incidence of persistent postsurgical use of opioids in adult patients and the associated risk factors.
Introduction:
Surgery has been identified as an independent risk factor for unwarranted chronic opioid use, contributing to opioid-related harm in the community. Persistent opioid use after surgery is associated with morbidity and mortality from opioid-related adverse events, indicating a significant yet mitigable public health concern. There is substantial variation in the reported incidence and risk factors for postoperative opioid use, which require evaluation for future evidence-based risk-reduction strategies.
Inclusion criteria:
This review will include studies investigating the persistent use of opioids after 90 postoperative days in adult (≥18 y) patients undergoing surgery of any type, including patients with cancer pain. Selected evidence must report on opioid use prior to surgery. Analytical and descriptive observational studies, and experimental and quasi-experimental studies, published in the previous decade will be eligible for inclusion.
Methods:
The proposed study methods follow the JBI methodology for systematic reviews of prevalence and incidence. A systematic search will be conducted in PubMed, Embase, CINAHL, Cochrane Central, and Web of Science, and a search of gray literature will include Google Scholar and ClinicalTrials.gov. Study selection, critical appraisal, and data extraction will be performed by 2 independent reviewers aided by the relevant JBI systematic review tools. We aim to produce a narrative synthesis of results and conduct a meta-analysis where feasible, in addition to subgroup analyses of suitable populations. The results are intended to promote safe, evidence-based postoperative opioid prescribing when considering risk factors for persistent postoperative opioid use.
Systematic review registration number:
PROSPERO CRD42022320691
UR - https://pearl.plymouth.ac.uk/context/nm-research/article/1107/viewcontent/JBI_20ES_20SR_20protocol_20HG_20revised_203.pdf
U2 - 10.11124/jbies-22-00106
DO - 10.11124/jbies-22-00106
M3 - Article
SN - 2202-4433
VL - 21
SP - 805
EP - 811
JO - JBI evidence synthesis
JF - JBI evidence synthesis
IS - 4
ER -
