Abstract
The deposition of fibrin in the peritoneal cavity leads to fibrous adhesion formation. Recombinant tissue plasminogen activator (rtPA), delivered locally, was investigated as a method of preventing adhesion formation. Six standardised areas of peritoneal ischaemia were formed in each of 36 male Wistar rats randomised to three intraperitoneal treatments: (A) no treatment control; (B) carboxymethylcellulose gel; (C) rtPA-carboxymethylcellulose gel combination. At 1 week all animals underwent relaparotomy and the number of ischaemic sites with an adhesion counted by an independent observer. rtPA-treated animals formed fewer adhesions compared with gel alone or controls (median number of adhesions 1.5 versus 2.5 versus 5, P < 0.001, ANOVA). Intraperitoneal rtPA in a slow-release formulation is able to reduce adhesion formation significantly in an animal model and may prove to have clinical benefit.
Original language | English |
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Pages (from-to) | 412-415 |
Number of pages | 0 |
Journal | Ann R Coll Surg Engl |
Volume | 76 |
Issue number | 6 |
Publication status | Published - Nov 1994 |
Keywords
- Administration
- Topical
- Animals
- Carboxymethylcellulose Sodium
- Drug Carriers
- Gels
- Laparotomy
- Male
- Peritoneal Diseases
- Rats
- Wistar
- Recombinant Proteins
- Tissue Adhesions
- Tissue Plasminogen Activator