Experimental adhesion prophylaxis with recombinant tissue plasminogen activator.

MN Vipond, SA Whawell, DM Scott-Coombes, JN Thompson, HA Dudley

Research output: Contribution to journalArticlepeer-review

Abstract

The deposition of fibrin in the peritoneal cavity leads to fibrous adhesion formation. Recombinant tissue plasminogen activator (rtPA), delivered locally, was investigated as a method of preventing adhesion formation. Six standardised areas of peritoneal ischaemia were formed in each of 36 male Wistar rats randomised to three intraperitoneal treatments: (A) no treatment control; (B) carboxymethylcellulose gel; (C) rtPA-carboxymethylcellulose gel combination. At 1 week all animals underwent relaparotomy and the number of ischaemic sites with an adhesion counted by an independent observer. rtPA-treated animals formed fewer adhesions compared with gel alone or controls (median number of adhesions 1.5 versus 2.5 versus 5, P < 0.001, ANOVA). Intraperitoneal rtPA in a slow-release formulation is able to reduce adhesion formation significantly in an animal model and may prove to have clinical benefit.
Original languageEnglish
Pages (from-to)412-415
Number of pages0
JournalAnn R Coll Surg Engl
Volume76
Issue number6
Publication statusPublished - Nov 1994

Keywords

  • Administration
  • Topical
  • Animals
  • Carboxymethylcellulose Sodium
  • Drug Carriers
  • Gels
  • Laparotomy
  • Male
  • Peritoneal Diseases
  • Rats
  • Wistar
  • Recombinant Proteins
  • Tissue Adhesions
  • Tissue Plasminogen Activator

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