TY - JOUR
T1 - Experience with lexicomp® online drug database for medication review and drug-drug interaction analysis within a comprehensive geriatric assessment in elderly cancer patients
AU - Debruyne, Philip R.
AU - Pottel, Lies
AU - Boterberg, Tom
AU - Lycke, Michelle
AU - Ketelaars, Lore
AU - Pottel, Hans
AU - Goethals, Laurence
AU - Van den Noortgate, Nele
AU - Duprez, Fréderic
AU - De Neve, Wilfried
AU - Rottey, Sylvie
AU - Geldhof, Kurt
AU - Van Eygen, Koen
AU - Kargar-Samani, Khalil
AU - Ghekiere, Véronique
AU - Verhaeghe, Anne
PY - 2012
Y1 - 2012
N2 - Background: We studied the use of Lexicomp®, an online drug information database, for adequate identification of drug-drug interactions (DDIs) within Comprehensive Geriatric Assessment (CGA) in cancer patients. Materials and Methods: Data of 149 onco-geriatric patients were reviewed. Sixty-three percent participated in an observational study recruiting head and neck cancer patients (H&N-group), 37% in a registry recruiting general oncology patients (GO-group). Baseline drug information was collected by a health professional, through the medical interview within CGA. Drug class usage was quantified and potential DDIs were assessed and categorized (risk rating "C": monitor therapy, "D": consider therapy modification, "X": avoid combination) with Lexicomp®. Results: On average, H&N and GO-patients took 5 and 8 prescription drugs at presentation, respectively. An average of 4 drugs were added in both groups as part of their proposed therapy. Potential DDIs (n=211 H&N; n=247 GO) were detected by Lexicomp® in 64.9% (85.3% "C", 14.7% "D", 0% "X") and 83.6% (83.4% "C", 15.8% "D", 0.8% "X") of H&N and GO patients, respectively, at therapy start. Administration of cancer-therapy-related drugs lead to additional DDIs (n=75 H&N; n=68 GO) in 73.7% and 58.3% of H&N and GO cases, respectively. DDIs occurred mainly with supportive drugs (100% H&N and 83.8% GO). Sixteen percent of potential DDIs were identified with anti-neoplastic drugs in the GO-group. In 28.7% and 60.0% of H&N and GO patients, respectively, at least one drug was not recognized by Lexicomp®. Conclusions: Use of Lexicomp® drug database within CGA is feasible. It could reduce the administration of inappropriate drugs, and in that way improve the quality of patient-individualized therapy.
AB - Background: We studied the use of Lexicomp®, an online drug information database, for adequate identification of drug-drug interactions (DDIs) within Comprehensive Geriatric Assessment (CGA) in cancer patients. Materials and Methods: Data of 149 onco-geriatric patients were reviewed. Sixty-three percent participated in an observational study recruiting head and neck cancer patients (H&N-group), 37% in a registry recruiting general oncology patients (GO-group). Baseline drug information was collected by a health professional, through the medical interview within CGA. Drug class usage was quantified and potential DDIs were assessed and categorized (risk rating "C": monitor therapy, "D": consider therapy modification, "X": avoid combination) with Lexicomp®. Results: On average, H&N and GO-patients took 5 and 8 prescription drugs at presentation, respectively. An average of 4 drugs were added in both groups as part of their proposed therapy. Potential DDIs (n=211 H&N; n=247 GO) were detected by Lexicomp® in 64.9% (85.3% "C", 14.7% "D", 0% "X") and 83.6% (83.4% "C", 15.8% "D", 0.8% "X") of H&N and GO patients, respectively, at therapy start. Administration of cancer-therapy-related drugs lead to additional DDIs (n=75 H&N; n=68 GO) in 73.7% and 58.3% of H&N and GO cases, respectively. DDIs occurred mainly with supportive drugs (100% H&N and 83.8% GO). Sixteen percent of potential DDIs were identified with anti-neoplastic drugs in the GO-group. In 28.7% and 60.0% of H&N and GO patients, respectively, at least one drug was not recognized by Lexicomp®. Conclusions: Use of Lexicomp® drug database within CGA is feasible. It could reduce the administration of inappropriate drugs, and in that way improve the quality of patient-individualized therapy.
KW - Cancer treatment
KW - Comprehensive geriatric assessment
KW - Drug-drug interactions
KW - Elderly cancer patients
KW - Lexicomp® online drug database
KW - Polypharmacy
KW - Safe prescription behavior
UR - http://www.scopus.com/inward/record.url?scp=84891557851&partnerID=8YFLogxK
U2 - 10.6000/1927-7229.2012.01.01.5
DO - 10.6000/1927-7229.2012.01.01.5
M3 - Article
AN - SCOPUS:84891557851
SN - 1927-7210
VL - 1
SP - 32
EP - 41
JO - Journal of Analytical Oncology
JF - Journal of Analytical Oncology
IS - 1
ER -