Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

Holly B. Posner; Stefan Cano; Maria C. Carrillo; Ola Selnes; Yaakov Stern; Ronald G. Thomas; John Zajicek; Jeremy Hobart

doi:10.1016/j.jalz.2012.10.008

Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

Holly B. Posner, Stefan Cano, Maria C. Carrillo^*, Ola Selnes, Yaakov Stern, Ronald G. Thomas, John Zajicek, Jeremy Hobart

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS‐Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS‐Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS‐Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

Original language	English
Number of pages	0
Journal	Alzheimer's & Dementia
Volume	9
Issue number	0
DOIs	https://doi.org/10.1016/j.jalz.2012.10.008
Publication status	Published - Feb 2013

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10.1016/j.jalz.2012.10.008

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abstract = "The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS‐Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS‐Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS‐Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.",

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AU - Carrillo, Maria C.

AU - Selnes, Ola

AU - Stern, Yaakov

AU - Thomas, Ronald G.

AU - Zajicek, John

AU - Hobart, Jeremy

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Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: A new approach

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