Endotoxin, cytokines and lipid peroxides in children with intussusception

I. E. Willetts; P. Kite; G. R. Barclay; R. E. Banks; A. Rumley; V. Allgar; M. D. Stringer

doi:10.1046/j.0007-1323.2001.01799.x

Endotoxin, cytokines and lipid peroxides in children with intussusception

I. E. Willetts, P. Kite, G. R. Barclay, R. E. Banks, A. Rumley, V. Allgar, M. D. Stringer^*

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

AbstractBackgroundIntussusception is a relatively common paediatric surgical emergency. The aim of this study was to investigate selected inflammatory mediators in children with acute intussusception and to identify potentially useful plasma markers of clinical outcome.MethodsClinical, radiographic, operative and pathological details were recorded prospectively of all children presenting to a single institution with a confirmed diagnosis of acute intussusception during 1 year. Paired acute and convalescent venous blood samples were collected in a standard manner for blinded analysis of the following: malondialdehyde, C-reactive protein (CRP), interleukin (IL) 6, neopterin, tumour necrosis factor α, endotoxin, and immunoglobulin (Ig) G and IgM antiendotoxin core antibody (EndoCAb).ResultsThirty-two consecutive children (23 boys, nine girls) with a median age of 4 months were studied. Acute ileocolic intussusception was managed by air enema reduction (n = 19), operative reduction (n = 8) or surgical resection (n = 5). Peripheral blood cultures were sterile. Acute levels of plasma IL-6, neopterin and CRP were significantly raised in comparison to both normal laboratory ranges and convalescent samples (P &lt; 0·001). Using stepwise discriminant analysis, CRP was identified as the best variable at distinguishing between the three treatment groups (P &lt; 0·001). IgM EndoCAb concentrations were significantly greater in the convalescent sera of all the patients (P &lt; 0·001).ConclusionAcute ileocolic intussusception in childhood is associated with endotoxinaemia and significantly raised levels of circulating inflammatory cytokines. Plasma CRP at diagnosis showed a statistically significant positive correlation with disease severity.

Original language	English
Pages (from-to)	878-883
Number of pages	0
Journal	British Journal of Surgery
Volume	88
Issue number	6
DOIs	https://doi.org/10.1046/j.0007-1323.2001.01799.x
Publication status	Published - 4 Dec 2002

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10.1046/j.0007-1323.2001.01799.x

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title = "Endotoxin, cytokines and lipid peroxides in children with intussusception",

abstract = "AbstractBackgroundIntussusception is a relatively common paediatric surgical emergency. The aim of this study was to investigate selected inflammatory mediators in children with acute intussusception and to identify potentially useful plasma markers of clinical outcome.MethodsClinical, radiographic, operative and pathological details were recorded prospectively of all children presenting to a single institution with a confirmed diagnosis of acute intussusception during 1 year. Paired acute and convalescent venous blood samples were collected in a standard manner for blinded analysis of the following: malondialdehyde, C-reactive protein (CRP), interleukin (IL) 6, neopterin, tumour necrosis factor α, endotoxin, and immunoglobulin (Ig) G and IgM antiendotoxin core antibody (EndoCAb).ResultsThirty-two consecutive children (23 boys, nine girls) with a median age of 4 months were studied. Acute ileocolic intussusception was managed by air enema reduction (n = 19), operative reduction (n = 8) or surgical resection (n = 5). Peripheral blood cultures were sterile. Acute levels of plasma IL-6, neopterin and CRP were significantly raised in comparison to both normal laboratory ranges and convalescent samples (P < 0·001). Using stepwise discriminant analysis, CRP was identified as the best variable at distinguishing between the three treatment groups (P < 0·001). IgM EndoCAb concentrations were significantly greater in the convalescent sera of all the patients (P < 0·001).ConclusionAcute ileocolic intussusception in childhood is associated with endotoxinaemia and significantly raised levels of circulating inflammatory cytokines. Plasma CRP at diagnosis showed a statistically significant positive correlation with disease severity.",

author = "Willetts, {I. E.} and P. Kite and Barclay, {G. R.} and Banks, {R. E.} and A. Rumley and V. Allgar and Stringer, {M. D.}",

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T1 - Endotoxin, cytokines and lipid peroxides in children with intussusception

AU - Willetts, I. E.

AU - Kite, P.

AU - Barclay, G. R.

AU - Banks, R. E.

AU - Rumley, A.

AU - Allgar, V.

AU - Stringer, M. D.

PY - 2002/12/4

Y1 - 2002/12/4

N2 - AbstractBackgroundIntussusception is a relatively common paediatric surgical emergency. The aim of this study was to investigate selected inflammatory mediators in children with acute intussusception and to identify potentially useful plasma markers of clinical outcome.MethodsClinical, radiographic, operative and pathological details were recorded prospectively of all children presenting to a single institution with a confirmed diagnosis of acute intussusception during 1 year. Paired acute and convalescent venous blood samples were collected in a standard manner for blinded analysis of the following: malondialdehyde, C-reactive protein (CRP), interleukin (IL) 6, neopterin, tumour necrosis factor α, endotoxin, and immunoglobulin (Ig) G and IgM antiendotoxin core antibody (EndoCAb).ResultsThirty-two consecutive children (23 boys, nine girls) with a median age of 4 months were studied. Acute ileocolic intussusception was managed by air enema reduction (n = 19), operative reduction (n = 8) or surgical resection (n = 5). Peripheral blood cultures were sterile. Acute levels of plasma IL-6, neopterin and CRP were significantly raised in comparison to both normal laboratory ranges and convalescent samples (P < 0·001). Using stepwise discriminant analysis, CRP was identified as the best variable at distinguishing between the three treatment groups (P < 0·001). IgM EndoCAb concentrations were significantly greater in the convalescent sera of all the patients (P < 0·001).ConclusionAcute ileocolic intussusception in childhood is associated with endotoxinaemia and significantly raised levels of circulating inflammatory cytokines. Plasma CRP at diagnosis showed a statistically significant positive correlation with disease severity.

AB - AbstractBackgroundIntussusception is a relatively common paediatric surgical emergency. The aim of this study was to investigate selected inflammatory mediators in children with acute intussusception and to identify potentially useful plasma markers of clinical outcome.MethodsClinical, radiographic, operative and pathological details were recorded prospectively of all children presenting to a single institution with a confirmed diagnosis of acute intussusception during 1 year. Paired acute and convalescent venous blood samples were collected in a standard manner for blinded analysis of the following: malondialdehyde, C-reactive protein (CRP), interleukin (IL) 6, neopterin, tumour necrosis factor α, endotoxin, and immunoglobulin (Ig) G and IgM antiendotoxin core antibody (EndoCAb).ResultsThirty-two consecutive children (23 boys, nine girls) with a median age of 4 months were studied. Acute ileocolic intussusception was managed by air enema reduction (n = 19), operative reduction (n = 8) or surgical resection (n = 5). Peripheral blood cultures were sterile. Acute levels of plasma IL-6, neopterin and CRP were significantly raised in comparison to both normal laboratory ranges and convalescent samples (P < 0·001). Using stepwise discriminant analysis, CRP was identified as the best variable at distinguishing between the three treatment groups (P < 0·001). IgM EndoCAb concentrations were significantly greater in the convalescent sera of all the patients (P < 0·001).ConclusionAcute ileocolic intussusception in childhood is associated with endotoxinaemia and significantly raised levels of circulating inflammatory cytokines. Plasma CRP at diagnosis showed a statistically significant positive correlation with disease severity.

U2 - 10.1046/j.0007-1323.2001.01799.x

DO - 10.1046/j.0007-1323.2001.01799.x

M3 - Article

SN - 0007-1323

VL - 88

SP - 878

EP - 883

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 6

ER -

Endotoxin, cytokines and lipid peroxides in children with intussusception

Abstract

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