Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Jeremy Chataway; Angelis F De; Peter Connick; RA Parker; Domenico Plantone; Anisha Doshi; Nevin John; Jonathan Stutters; David MacManus; Carrasco F Prados; Frederik Barkhof; Sebastien Ourselin; Marie Braisher; Moira Ross; Gina Cranswick; Sue H. Pavitt; Gavin Giovannoni; Wheeler-Kingshott CA Gandini; Clive Hawkins; Basil Sharrack; Roger Bastow; Christopher J. Weir; Nigel Stallard; Siddharthan Chandran; Jeremy Chataway; Wheeler-Kingshott CAM Gandini; Angelis F De; Domenico Plantone; Anisha Doshi; Nevin John; Thomas Williams; Marie Braisher; Tiggy Beyene; Vanessa Bassan; Alvin Zapata; Siddharthan Chandran; Peter Connick; Dawn Lyle; James Cameron; Daisy Mollison; Shuna Colville; Baljean Dhillon; Christopher J. Weir; RA Parker; Moira Ross; Gina Cranswick; Gavin Giovannoni; Sharmilee Gnanapavan; Richard Nicholas; Waqar Rashid; Julia Aram; Helen Ford; James Overell; Carolyn Young; Heinke Arndt; Martin Duddy; Joe Guadagno; Nikolaos Evangelou; Matthew Craner; Jacqueline Palace; Jeremy Hobart; Basil Sharrack; David Paling; Clive Hawkins; Seema Kalra; B McLean; Nigel Stallard; Roger Bastow

doi:10.1016/s1474-4422(19)30485-5

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Jeremy Chataway^*
, Angelis F De
, Peter Connick
, RA Parker
, Domenico Plantone
, Anisha Doshi
, Nevin John
, Jonathan Stutters
, David MacManus
, Carrasco F Prados
, Frederik Barkhof
, Sebastien Ourselin
, Marie Braisher
, Moira Ross
, Gina Cranswick
, Sue H. Pavitt
, Gavin Giovannoni
, Wheeler-Kingshott CA Gandini
, Clive Hawkins
, Basil Sharrack

Roger Bastow, Christopher J. Weir, Nigel Stallard, Siddharthan Chandran, Jeremy Chataway^*, Wheeler-Kingshott CAM Gandini, Angelis F De, Domenico Plantone, Anisha Doshi, Nevin John, Thomas Williams, Marie Braisher, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Siddharthan Chandran, Peter Connick, Dawn Lyle, James Cameron, Daisy Mollison, Shuna Colville, Baljean Dhillon, Christopher J. Weir, RA Parker, Moira Ross, Gina Cranswick, Gavin Giovannoni, Sharmilee Gnanapavan, Richard Nicholas, Waqar Rashid, Julia Aram, Helen Ford, James Overell, Carolyn Young, Heinke Arndt, Martin Duddy, Joe Guadagno, Nikolaos Evangelou, Matthew Craner, Jacqueline Palace, Jeremy Hobart, Basil Sharrack, David Paling, Clive Hawkins, Seema Kalra, B McLean, Nigel Stallard, Roger Bastow

^*Corresponding author for this work

Peninsula Medical School

University College London
University of Edinburgh
VU University Medical Center
King's College London
University of Leeds
Queen Mary University of London
Keele University
Royal Hallamshire Hospital
Multiple Sclerosis Society
University of Warwick

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	214-225
Number of pages	0
Journal	The Lancet Neurology
Volume	19
Issue number	3
Early online date	22 Jan 2020
DOIs	https://doi.org/10.1016/s1474-4422(19)30485-5
Publication status	Published - Mar 2020

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SDG 3 Good Health and Well-being

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10.1016/s1474-4422(19)30485-5

Efficacy of three neuroprotective drugs in seconda

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Chataway, J., De, A. F., Connick, P., Parker, RA., Plantone, D., Doshi, A., John, N., Stutters, J., MacManus, D., Prados, C. F., Barkhof, F., Ourselin, S., Braisher, M., Ross, M., Cranswick, G., Pavitt, S. H., Giovannoni, G., Gandini, W.-K. CA., Hawkins, C., ... Bastow, R. (2020). Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial. The Lancet Neurology, 19(3), 214-225. https://doi.org/10.1016/s1474-4422(19)30485-5

@article{fd1ccad910334dd2a056b54039294fc3,

title = "Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial",

author = "Jeremy Chataway and De, \{Angelis F\} and Peter Connick and RA Parker and Domenico Plantone and Anisha Doshi and Nevin John and Jonathan Stutters and David MacManus and Prados, \{Carrasco F\} and Frederik Barkhof and Sebastien Ourselin and Marie Braisher and Moira Ross and Gina Cranswick and Pavitt, \{Sue H.\} and Gavin Giovannoni and Gandini, \{Wheeler-Kingshott CA\} and Clive Hawkins and Basil Sharrack and Roger Bastow and Weir, \{Christopher J.\} and Nigel Stallard and Siddharthan Chandran and Jeremy Chataway and Gandini, \{Wheeler-Kingshott CAM\} and De, \{Angelis F\} and Domenico Plantone and Anisha Doshi and Nevin John and Thomas Williams and Marie Braisher and Tiggy Beyene and Vanessa Bassan and Alvin Zapata and Siddharthan Chandran and Peter Connick and Dawn Lyle and James Cameron and Daisy Mollison and Shuna Colville and Baljean Dhillon and Weir, \{Christopher J.\} and RA Parker and Moira Ross and Gina Cranswick and Gavin Giovannoni and Sharmilee Gnanapavan and Richard Nicholas and Waqar Rashid and Julia Aram and Helen Ford and James Overell and Carolyn Young and Heinke Arndt and Martin Duddy and Joe Guadagno and Nikolaos Evangelou and Matthew Craner and Jacqueline Palace and Jeremy Hobart and Basil Sharrack and David Paling and Clive Hawkins and Seema Kalra and B McLean and Nigel Stallard and Roger Bastow",

year = "2020",

month = mar,

doi = "10.1016/s1474-4422(19)30485-5",

language = "English",

volume = "19",

pages = "214--225",

journal = "The Lancet Neurology",

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Chataway, J, De, AF, Connick, P, Parker, RA, Plantone, D, Doshi, A, John, N, Stutters, J, MacManus, D, Prados, CF, Barkhof, F, Ourselin, S, Braisher, M, Ross, M, Cranswick, G, Pavitt, SH, Giovannoni, G, Gandini, W-KCA, Hawkins, C, Sharrack, B, Bastow, R, Weir, CJ, Stallard, N, Chandran, S, Chataway, J, Gandini, W-KCAM, De, AF, Plantone, D, Doshi, A, John, N, Williams, T, Braisher, M, Beyene, T, Bassan, V, Zapata, A, Chandran, S, Connick, P, Lyle, D, Cameron, J, Mollison, D, Colville, S, Dhillon, B, Weir, CJ, Parker, RA, Ross, M, Cranswick, G, Giovannoni, G, Gnanapavan, S, Nicholas, R, Rashid, W, Aram, J, Ford, H, Overell, J, Young, C, Arndt, H, Duddy, M, Guadagno, J, Evangelou, N, Craner, M, Palace, J, Hobart, J, Sharrack, B, Paling, D, Hawkins, C, Kalra, S, McLean, B, Stallard, N & Bastow, R 2020, 'Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial', The Lancet Neurology, vol. 19, no. 3, pp. 214-225. https://doi.org/10.1016/s1474-4422(19)30485-5

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AU - Plantone, Domenico

AU - Doshi, Anisha

AU - John, Nevin

AU - Stutters, Jonathan

AU - MacManus, David

AU - Prados, Carrasco F

AU - Barkhof, Frederik

AU - Ourselin, Sebastien

AU - Braisher, Marie

AU - Ross, Moira

AU - Cranswick, Gina

AU - Pavitt, Sue H.

AU - Giovannoni, Gavin

AU - Gandini, Wheeler-Kingshott CA

AU - Hawkins, Clive

AU - Sharrack, Basil

AU - Bastow, Roger

AU - Weir, Christopher J.

AU - Stallard, Nigel

AU - Chandran, Siddharthan

AU - Chataway, Jeremy

AU - Gandini, Wheeler-Kingshott CAM

AU - De, Angelis F

AU - Plantone, Domenico

AU - Doshi, Anisha

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AU - Williams, Thomas

AU - Braisher, Marie

AU - Beyene, Tiggy

AU - Bassan, Vanessa

AU - Zapata, Alvin

AU - Chandran, Siddharthan

AU - Connick, Peter

AU - Lyle, Dawn

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AU - Dhillon, Baljean

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AU - Cranswick, Gina

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AU - Rashid, Waqar

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AU - Ford, Helen

AU - Overell, James

AU - Young, Carolyn

AU - Arndt, Heinke

AU - Duddy, Martin

AU - Guadagno, Joe

AU - Evangelou, Nikolaos

AU - Craner, Matthew

AU - Palace, Jacqueline

AU - Hobart, Jeremy

AU - Sharrack, Basil

AU - Paling, David

AU - Hawkins, Clive

AU - Kalra, Seema

AU - McLean, B

AU - Stallard, Nigel

AU - Bastow, Roger

PY - 2020/3

Y1 - 2020/3

UR - https://pearl.plymouth.ac.uk/pms-research/507/

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SN - 1474-4422

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JO - The Lancet Neurology

JF - The Lancet Neurology

IS - 3

ER -

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

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