Dynamics of the cerebral autoregulatory response to paced hyperventilation assessed using subcomponent and time-varying analyses

Rebecca H. Clough, Jatinder S. Minhas, Victoria J. Haunton, Martha F. Hanby, Thompson G. Robinson, Ronney B. Panerai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

<jats:p> The dynamic response of critical closing pressure (CrCP) and resistance-area product (RAP) of the cerebral circulation to a step change in mean arterial pressure can shed light on the nonstationary changes induced by paced hyperventilation and the effects of hypocapnia on the autoregulation of cerebral blood flow. Contrary to hypercapnia, where the response is dominated by CrCP, hypocapnia shows an initial depression of cerebral autoregulation, followed by improvements controlled by changes in RAP. </jats:p>
Original languageEnglish
Pages (from-to)311-319
Number of pages0
JournalJournal of Applied Physiology
Volume133
Issue number2
DOIs
Publication statusPublished - 1 Aug 2022

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