Do metronomes improve the quality of life in people with Parkinson’s disease? A pragmatic, single-blind, randomized cross-over trial

Julian Elston*, Will Honan, Roy Powell, Joe Gormley, Ken Stein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

<jats:p> Objective: To evaluate the effect of acoustic cueing using metronomes on the quality of life of people with moderate to severe Parkinson’s disease. </jats:p><jats:p> Study design: Pragmatic, single-blind, randomized cross-over trial. </jats:p><jats:p> Participants: Forty-two people aged 50—85 years, in Hoehn and Yahr stage II—IV and on stable medication. Eight were lost to follow-up. </jats:p><jats:p> Intervention: Participants were randomized using concealed allocation to either an early group (n = 21) to receive an electronic metronome without therapy but limited support (5—10 minutes instruction and on-demand telephone assistance) for four weeks, or a late group (n = 21) to receive the same intervention at 10 weeks. In both groups the beat frequency was initially set to be comfortable for walking. </jats:p><jats:p> Outcomes measures: Primary and secondary outcomes were measured at baseline, 4, 10 and 14 weeks using the Parkinson’s Disease Questionnaire 39 (PDQ-39), the Short Form 36 version 2 (SF-36 version 2) and a falls diary. </jats:p><jats:p> Results: There were positive effects in six domains of the SF-36 version 2 and eight domains of the PDQ-39, although only one mean difference was clinically important: the role limitation (emotional) domain of SF-36 version 2 (a mean difference of 3.77, 95% confidence interval (CI), —2.68 to 10.22), a secondary outcome. None of these changes were statistically significant. There were no statistically significant differences in falls rates over the study period. Ten participants (24%) wanted to continue with their metronomes at the end of the study. </jats:p><jats:p> Conclusion: To demonstrate metronomes are beneficial on the role limitation domain of the SF-36 version 2 in people with moderate to severe Parkinson’s disease a sample size of 600 would be required. </jats:p>
Original languageEnglish
Pages (from-to)523-532
Number of pages0
JournalClinical Rehabilitation
Volume24
Issue number6
Early online date18 May 2010
DOIs
Publication statusPublished - Jun 2010

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