Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates

M. T. Drott*, R. W. Bastos, A. Rokas, L. N.A. Ries, T. Gabaldón, G. H. Goldman, N. P. Keller, C. Greco*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

<jats:p>Much of what we know about the genetics underlying secondary metabolite (SM) production and the function of SMs in the model fungus<jats:named-content content-type="genus-species">Aspergillus nidulans</jats:named-content>comes from a single reference genome. A growing body of research indicates the importance of biosynthetic gene cluster (BGC) and SM diversity within a species. However, there is no information about the natural diversity of secondary metabolism in<jats:named-content content-type="genus-species">A. nidulans</jats:named-content>. We discovered six novel clusters that contribute to the considerable variation in both BGC content and SM production within<jats:named-content content-type="genus-species">A. nidulans</jats:named-content>. We characterize a diverse set of mutations and emphasize how findings of single nucleotide polymorphisms (SNPs), deletions, and differences in evolutionary history encompass much of the variation observed in nonmodel systems. Our results emphasize that<jats:named-content content-type="genus-species">A. nidulans</jats:named-content>may also be a strong model to use within-species diversity to elucidate regulatory cross talk, fungal ecology, and drug discovery systems.</jats:p>
Original languageEnglish
Number of pages0
JournalmSphere
Volume5
Issue number2
DOIs
Publication statusPublished - 29 Apr 2020

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