Abstract
Some AMPA receptors are permeable to Ca2+. It has been suggested that cultured rat cerebellar granule cells express Ca(2+)-permeable AMPA receptors, but their distribution at a single cell level is unknown. We report that AMPA (in the presence of cyclothiazide) induced Ca2+ entry (measured by Mn2+ quench of fura-2 fluorescence) and intracellular Ca2+ increases in cerebellar granule cells in the absence of extracellular Na+, supporting the presence of Ca(2+)-permeable AMPA receptors. Analysis of intracellular Ca2+ signals in single cells demonstrated a heterogeneous distribution of Ca(2+)-permeable AMPA receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 1877-1882 |
| Number of pages | 0 |
| Journal | NeuroReport |
| Volume | 8 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 27 May 1997 |
Keywords
- Animals
- Benzothiadiazines
- Calcium
- Cells
- Cultured
- Cerebellum
- Culture Media
- Serum-Free
- Diuretics
- Dizocilpine Maleate
- Excitatory Amino Acid Agonists
- Excitatory Amino Acid Antagonists
- Fluorescent Dyes
- Fura-2
- Manganese
- Quinoxalines
- Rats
- Receptors
- AMPA
- Sodium Chloride Symporter Inhibitors
- alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid