TY - JOUR
T1 - Diagnostic Performance of Screening Tools for Depressive Symptoms in Vulnerable Older Patients with Cancer Undergoing Comprehensive Geriatric Assessment (CGA): Results from the SCREEN Pilot Study
AU - Tack, Laura
AU - Maenhoudt, Ann Sophie
AU - Ketelaars, Lore
AU - De, Zutter J
AU - Pinson, Stefanie
AU - Keunebrock, Laura
AU - Haaker, Lorenz
AU - Deckmyn, Kathleen
AU - Gheysen, Mathilde
AU - Kenis, Cindy
AU - Wildiers, Hans
AU - Depoorter, Laurence
AU - Geerts, Pieter Jan
AU - Chandler, Rebecca
AU - Boterberg, Tom
AU - Schofield, Patricia
AU - Parris, Christopher N.
AU - Debruyne, Philip R.
PY - 2023/2/2
Y1 - 2023/2/2
N2 - Depression is a common and disabling disorder in later life, particularly among people with poor physical health. There are many screening tools available that can be used to examine depressive symptoms; however, not all of them may be appropriate or accurate for older adults with cancer. This pilot study was designed to test the diagnostic performance of two screening tools and their short versions in a cohort of vulnerable (G8 score ≤ 14/17) older patients with cancer undergoing comprehensive geriatric assessment (CGA). The prospective analysis covered 50 vulnerable patients with cancer aged ≥70 years. The diagnostic performance of the Geriatric Depression Scale (GDS)-15, GDS-4, Patient Health Questionnaire (PHQ)-9 and PHQ-2 was compared to the ‘gold standard’ Structured Clinical Interview for DSM-5 Disorders (SCID-5-S) depression module A. The sensitivity and specificity in detecting depressive symptoms were the highest in the case of PHQ-2, with an area under the receiver operating characteristic curve (AUROC) of 92.7%. The AUROC for the 9-item version, PHQ-9, was 90.2%. For the GDS-15 and GDS-4, the AUROC was only 56.2% and 62.0%, respectively. The SCREEN pilot study illustrates the potential benefit of using a shorter screening tool, PHQ-2, to identify older patients with cancer who would benefit from a more in-depth emotional evaluation as part of a CGA.
AB - Depression is a common and disabling disorder in later life, particularly among people with poor physical health. There are many screening tools available that can be used to examine depressive symptoms; however, not all of them may be appropriate or accurate for older adults with cancer. This pilot study was designed to test the diagnostic performance of two screening tools and their short versions in a cohort of vulnerable (G8 score ≤ 14/17) older patients with cancer undergoing comprehensive geriatric assessment (CGA). The prospective analysis covered 50 vulnerable patients with cancer aged ≥70 years. The diagnostic performance of the Geriatric Depression Scale (GDS)-15, GDS-4, Patient Health Questionnaire (PHQ)-9 and PHQ-2 was compared to the ‘gold standard’ Structured Clinical Interview for DSM-5 Disorders (SCID-5-S) depression module A. The sensitivity and specificity in detecting depressive symptoms were the highest in the case of PHQ-2, with an area under the receiver operating characteristic curve (AUROC) of 92.7%. The AUROC for the 9-item version, PHQ-9, was 90.2%. For the GDS-15 and GDS-4, the AUROC was only 56.2% and 62.0%, respectively. The SCREEN pilot study illustrates the potential benefit of using a shorter screening tool, PHQ-2, to identify older patients with cancer who would benefit from a more in-depth emotional evaluation as part of a CGA.
UR - https://pearl.plymouth.ac.uk/context/nm-research/article/1526/viewcontent/Diagnostic_20Performance_20of_20Screening_20Tools_20for_20Depressive.pdf
U2 - 10.3390/curroncol30020140
DO - 10.3390/curroncol30020140
M3 - Article
SN - 1718-7729
VL - 30
SP - 1805
EP - 1817
JO - Current Oncology
JF - Current Oncology
IS - 2
ER -
