Diagnosing Pulmonary Tuberculosis in the Elderly

Michael J. Symes; Ben Probyn; Cyrus Daneshvar; Lilanganee Telisinghe

doi:10.1007/s13670-020-00319-5

Diagnosing Pulmonary Tuberculosis in the Elderly

Michael J. Symes
, Ben Probyn
, Cyrus Daneshvar^*
, Lilanganee Telisinghe

^*Corresponding author for this work

University Hospitals Plymouth NHS Trust
London School of Hygiene and Tropical Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of Review: Pulmonary tuberculosis (TB) remains a diagnostic challenge, particularly in low endemic settings with ageing populations. The impact has both individual and infection control implications. Recent Findings: Over the past 20 years, progress has been made in trying to improve TB diagnostics. International recommendations for investigation however still rely heavily on the index of suspicion, imaging and ultimately culturing Mycobacterium tuberculosis which remains the gold standard for diagnosing TB disease. Recent advances include molecular diagnostics with the ability to rapidly identify TB disease and drug resistance and whole-genome sequencing. Summary: In this review, we explore the validity of TB diagnostics in the elderly to assist the practicing clinician in the diagnostic workup in this population.

Original language	English
Pages (from-to)	30-39
Number of pages	10
Journal	Current Geriatrics Reports
Volume	9
Issue number	2
DOIs	https://doi.org/10.1007/s13670-020-00319-5
Publication status	Published - 1 Jun 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Geriatrics and Gerontology

Keywords

Diagnostics
Elderly
Imaging
Mycobacterium tuberculosis
Sputum microscopy
Whole-genome sequencing

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10.1007/s13670-020-00319-5

Cite this

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title = "Diagnosing Pulmonary Tuberculosis in the Elderly",

abstract = "Purpose of Review: Pulmonary tuberculosis (TB) remains a diagnostic challenge, particularly in low endemic settings with ageing populations. The impact has both individual and infection control implications. Recent Findings: Over the past 20 years, progress has been made in trying to improve TB diagnostics. International recommendations for investigation however still rely heavily on the index of suspicion, imaging and ultimately culturing Mycobacterium tuberculosis which remains the gold standard for diagnosing TB disease. Recent advances include molecular diagnostics with the ability to rapidly identify TB disease and drug resistance and whole-genome sequencing. Summary: In this review, we explore the validity of TB diagnostics in the elderly to assist the practicing clinician in the diagnostic workup in this population.",

keywords = "Diagnostics, Elderly, Imaging, Mycobacterium tuberculosis, Sputum microscopy, Whole-genome sequencing",

author = "Symes, \{Michael J.\} and Ben Probyn and Cyrus Daneshvar and Lilanganee Telisinghe",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature.",

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doi = "10.1007/s13670-020-00319-5",

language = "English",

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T1 - Diagnosing Pulmonary Tuberculosis in the Elderly

AU - Symes, Michael J.

AU - Probyn, Ben

AU - Daneshvar, Cyrus

AU - Telisinghe, Lilanganee

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Purpose of Review: Pulmonary tuberculosis (TB) remains a diagnostic challenge, particularly in low endemic settings with ageing populations. The impact has both individual and infection control implications. Recent Findings: Over the past 20 years, progress has been made in trying to improve TB diagnostics. International recommendations for investigation however still rely heavily on the index of suspicion, imaging and ultimately culturing Mycobacterium tuberculosis which remains the gold standard for diagnosing TB disease. Recent advances include molecular diagnostics with the ability to rapidly identify TB disease and drug resistance and whole-genome sequencing. Summary: In this review, we explore the validity of TB diagnostics in the elderly to assist the practicing clinician in the diagnostic workup in this population.

AB - Purpose of Review: Pulmonary tuberculosis (TB) remains a diagnostic challenge, particularly in low endemic settings with ageing populations. The impact has both individual and infection control implications. Recent Findings: Over the past 20 years, progress has been made in trying to improve TB diagnostics. International recommendations for investigation however still rely heavily on the index of suspicion, imaging and ultimately culturing Mycobacterium tuberculosis which remains the gold standard for diagnosing TB disease. Recent advances include molecular diagnostics with the ability to rapidly identify TB disease and drug resistance and whole-genome sequencing. Summary: In this review, we explore the validity of TB diagnostics in the elderly to assist the practicing clinician in the diagnostic workup in this population.

KW - Diagnostics

KW - Elderly

KW - Imaging

KW - Mycobacterium tuberculosis

KW - Sputum microscopy

KW - Whole-genome sequencing

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DO - 10.1007/s13670-020-00319-5

M3 - Review article

AN - SCOPUS:85083853169

SN - 2162-4941

VL - 9

SP - 30

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JO - Current Geriatrics Reports

JF - Current Geriatrics Reports

IS - 2

ER -

Diagnosing Pulmonary Tuberculosis in the Elderly

Abstract

UN SDGs

ASJC Scopus subject areas

Keywords

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