Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns; Madeleine Richer; Simona Jasaityte; Eleanor J. Stafford; Julie Joubert; Tarek Antar; Alejandro Martinez-Carrasco; Mary B. Makarious; Bradford Casey; Dan Vitale; K Levine; Hampton Leonard; Caroline B. Pantazis; LA Screven; DG Hernandez; CE Wegel; J Solle; Mike A. Nalls; Cornelis Blauwendraat; Andrew B. Singleton; MMX Tan; Hirotaka Iwaki; Huw R. Morris; Emilia M. Gatto; Marcelo Kauffman; Samson Khachatryan; Zaruhi Tavadyan; Claire E. Shepherd; Julie Hunter; Kishore Kumar; Melina Ellis; Miguel E. Rentería; Sulev Koks; Alexander Zimprich; Artur F. Schumacher-Schuh; Carlos Rieder; Paula Saffie Awad; Vitor Tumas; Sarah Camargos; EA Fon; Oury Monchi; T Fon; Benjamin Pizarro Galleguillos; Marcelo Miranda; Maria Leonor Bustamante; Patricio Olguin; Pedro Chana; Beisha Tang; Huifang Shang; Jifeng Guo; P Chan; Wei Luo; Gonzalo Arboleda; Jorge Orozco; Rio MJ del; A Hernandez; Mohamed Salama; Walaa A. Kamel; Yared Z. Zewde; Alexis Brice; Jean Christophe Corvol; Ana Westenberger; Anastasia Illarionova; Brit Mollenhauer; Christine Klein; Eva Juliane Vollstedt; Franziska Hopfner; Günter Höglinger; Harutyun Madoev; Joanne Trinh; Johanna Junker; Katja Lohmann; Lara M. Lange; Manu Sharma; Sergiu Groppa; Thomas Gasser; Zih Hua Fang; Albert Akpalu; Georgia Xiromerisiou; Georgios Hadjigorgiou; Ioannis Dagklis; Ioannis Tarnanas; Leonidas Stefanis; Maria Stamelou; Efthymios Dadiotis; Alex Medina; GH-F Chan; Nancy Ip; Nelson Yuk Fai Cheung; Camille Carroll

doi:10.1038/s41531-023-00533-w

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns
, Madeleine Richer
, Simona Jasaityte
, Eleanor J. Stafford
, Julie Joubert
, Tarek Antar
, Alejandro Martinez-Carrasco
, Mary B. Makarious
, Bradford Casey
, Dan Vitale
, K Levine
, Hampton Leonard
, Caroline B. Pantazis
, LA Screven
, DG Hernandez
, CE Wegel
, J Solle
, Mike A. Nalls
, Cornelis Blauwendraat
, Andrew B. Singleton

MMX Tan, Hirotaka Iwaki, Huw R. Morris^*, Emilia M. Gatto, Marcelo Kauffman, Samson Khachatryan, Zaruhi Tavadyan, Claire E. Shepherd, Julie Hunter, Kishore Kumar, Melina Ellis, Miguel E. Rentería, Sulev Koks, Alexander Zimprich, Artur F. Schumacher-Schuh, Carlos Rieder, Paula Saffie Awad, Vitor Tumas, Sarah Camargos, EA Fon, Oury Monchi, T Fon, Benjamin Pizarro Galleguillos, Marcelo Miranda, Maria Leonor Bustamante, Patricio Olguin, Pedro Chana, Beisha Tang, Huifang Shang, Jifeng Guo, P Chan, Wei Luo, Gonzalo Arboleda, Jorge Orozco, Rio MJ del, A Hernandez, Mohamed Salama, Walaa A. Kamel, Yared Z. Zewde, Alexis Brice, Jean Christophe Corvol, Ana Westenberger, Anastasia Illarionova, Brit Mollenhauer, Christine Klein, Eva Juliane Vollstedt, Franziska Hopfner, Günter Höglinger, Harutyun Madoev, Joanne Trinh, Johanna Junker, Katja Lohmann, Lara M. Lange, Manu Sharma, Sergiu Groppa, Thomas Gasser, Zih Hua Fang, Albert Akpalu, Georgia Xiromerisiou, Georgios Hadjigorgiou, Ioannis Dagklis, Ioannis Tarnanas, Leonidas Stefanis, Maria Stamelou, Efthymios Dadiotis, Alex Medina, GH-F Chan, Nancy Ip, Nelson Yuk Fai Cheung, Camille Carroll

^*Corresponding author for this work

Peninsula Medical School

University College London
National Institutes of Health
Michael J. Fox Foundation for Parkinson's Research
Data Tecnica International
Sanatorio de la Trinidad
Hospital General de Agudos José María Ramos Mejía
Somnus Neurology Clinic
Neuroscience Research Australia
ANZAC Research Institute
Garvan Institute of Medical Research
Concord Repatriation General Hospital
Queensland Institute of Medical Research
Murdoch University
University of Vienna
Universidade Federal do Rio Grande do Sul
Universidade Federal de Ciências da Saúde de Porto Alegre
Universidade de São Paulo
Universidade Federal de Minas Gerais
University of Montreal
Universidad de Chile
Fundación Diagnosis
CETRAM
Central South University
Sichuan University
Zhejiang University
Universidad Nacional de Colombia
Fundación Valle del Lili
American University in Cairo
Beni-Suef University
Addis Ababa University
Université Pierre et Marie Curie (UPMC)
Sorbonne Université
University of Lübeck
German Center for Neurodegenerative Diseases
University of Göttingen
Ludwig Maximilian University of Munich
Universitätsklinikum Schleswig-Holstein Campus Lübeck
University of Tübingen
Johannes Gutenberg University Mainz
University of Ghana
University of Thessaly
Aristotle University of Thessaloniki
Ionian University
Academy of Athens
Hygeia Hospital
Hospital San Felipe
Hong Kong University of Science and Technology
Queen Elizabeth Hospital Hong Kong

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Abstract

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

Original language	English
Number of pages	0
Journal	npj Parkinson's Disease
Volume	9
Issue number	1
Early online date	12 Sept 2023
DOIs	https://doi.org/10.1038/s41531-023-00533-w
Publication status	Published - 12 Sept 2023

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Defining the causes of sporadic Parkinsons disease in the global Parkinsons genetics program (GP2)Final published version, 1.32 MB

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Towns, C., Richer, M., Jasaityte, S., Stafford, E. J., Joubert, J., Antar, T., Martinez-Carrasco, A., Makarious, M. B., Casey, B., Vitale, D., Levine, K., Leonard, H., Pantazis, C. B., Screven, LA., Hernandez, DG., Wegel, CE., Solle, J., Nalls, M. A., Blauwendraat, C., ... Carroll, C. (2023). Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2). npj Parkinson's Disease, 9(1). https://doi.org/10.1038/s41531-023-00533-w

@article{4012fb23c53e4f9eb6e5b840b64f2227,

title = "Defining the causes of sporadic Parkinson{\textquoteright}s disease in the global Parkinson{\textquoteright}s genetics program (GP2)",

abstract = "The Global Parkinson{\textquoteright}s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.",

author = "Clodagh Towns and Madeleine Richer and Simona Jasaityte and Stafford, \{Eleanor J.\} and Julie Joubert and Tarek Antar and Alejandro Martinez-Carrasco and Makarious, \{Mary B.\} and Bradford Casey and Dan Vitale and K Levine and Hampton Leonard and Pantazis, \{Caroline B.\} and LA Screven and DG Hernandez and CE Wegel and J Solle and Nalls, \{Mike A.\} and Cornelis Blauwendraat and Singleton, \{Andrew B.\} and MMX Tan and Hirotaka Iwaki and Morris, \{Huw R.\} and Gatto, \{Emilia M.\} and Marcelo Kauffman and Samson Khachatryan and Zaruhi Tavadyan and Shepherd, \{Claire E.\} and Julie Hunter and Kishore Kumar and Melina Ellis and Renter{\'i}a, \{Miguel E.\} and Sulev Koks and Alexander Zimprich and Schumacher-Schuh, \{Artur F.\} and Carlos Rieder and Awad, \{Paula Saffie\} and Vitor Tumas and Sarah Camargos and EA Fon and Oury Monchi and T Fon and Galleguillos, \{Benjamin Pizarro\} and Marcelo Miranda and Bustamante, \{Maria Leonor\} and Patricio Olguin and Pedro Chana and Beisha Tang and Huifang Shang and Jifeng Guo and P Chan and Wei Luo and Gonzalo Arboleda and Jorge Orozco and del, \{Rio MJ\} and A Hernandez and Mohamed Salama and Kamel, \{Walaa A.\} and Zewde, \{Yared Z.\} and Alexis Brice and Corvol, \{Jean Christophe\} and Ana Westenberger and Anastasia Illarionova and Brit Mollenhauer and Christine Klein and Vollstedt, \{Eva Juliane\} and Franziska Hopfner and G{\"u}nter H{\"o}glinger and Harutyun Madoev and Joanne Trinh and Johanna Junker and Katja Lohmann and Lange, \{Lara M.\} and Manu Sharma and Sergiu Groppa and Thomas Gasser and Fang, \{Zih Hua\} and Albert Akpalu and Georgia Xiromerisiou and Georgios Hadjigorgiou and Ioannis Dagklis and Ioannis Tarnanas and Leonidas Stefanis and Maria Stamelou and Efthymios Dadiotis and Alex Medina and GH-F Chan and Nancy Ip and Cheung, \{Nelson Yuk Fai\} and Camille Carroll",

year = "2023",

month = sep,

day = "12",

doi = "10.1038/s41531-023-00533-w",

language = "English",

volume = "9",

journal = "npj Parkinson's Disease",

issn = "2373-8057",

publisher = "Nature Research",

number = "1",

}

Towns, C, Richer, M, Jasaityte, S, Stafford, EJ, Joubert, J, Antar, T, Martinez-Carrasco, A, Makarious, MB, Casey, B, Vitale, D, Levine, K, Leonard, H, Pantazis, CB, Screven, LA, Hernandez, DG, Wegel, CE, Solle, J, Nalls, MA, Blauwendraat, C, Singleton, AB, Tan, MMX, Iwaki, H, Morris, HR, Gatto, EM, Kauffman, M, Khachatryan, S, Tavadyan, Z, Shepherd, CE, Hunter, J, Kumar, K, Ellis, M, Rentería, ME, Koks, S, Zimprich, A, Schumacher-Schuh, AF, Rieder, C, Awad, PS, Tumas, V, Camargos, S, Fon, EA, Monchi, O, Fon, T, Galleguillos, BP, Miranda, M, Bustamante, ML, Olguin, P, Chana, P, Tang, B, Shang, H, Guo, J, Chan, P, Luo, W, Arboleda, G, Orozco, J, del, RMJ, Hernandez, A, Salama, M, Kamel, WA, Zewde, YZ, Brice, A, Corvol, JC, Westenberger, A, Illarionova, A, Mollenhauer, B, Klein, C, Vollstedt, EJ, Hopfner, F, Höglinger, G, Madoev, H, Trinh, J, Junker, J, Lohmann, K, Lange, LM, Sharma, M, Groppa, S, Gasser, T, Fang, ZH, Akpalu, A, Xiromerisiou, G, Hadjigorgiou, G, Dagklis, I, Tarnanas, I, Stefanis, L, Stamelou, M, Dadiotis, E, Medina, A, Chan, GH-F, Ip, N, Cheung, NYF & Carroll, C 2023, 'Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)', npj Parkinson's Disease, vol. 9, no. 1. https://doi.org/10.1038/s41531-023-00533-w

TY - JOUR

T1 - Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

AU - Towns, Clodagh

AU - Richer, Madeleine

AU - Jasaityte, Simona

AU - Stafford, Eleanor J.

AU - Joubert, Julie

AU - Antar, Tarek

AU - Martinez-Carrasco, Alejandro

AU - Makarious, Mary B.

AU - Casey, Bradford

AU - Vitale, Dan

AU - Levine, K

AU - Leonard, Hampton

AU - Pantazis, Caroline B.

AU - Screven, LA

AU - Hernandez, DG

AU - Wegel, CE

AU - Solle, J

AU - Nalls, Mike A.

AU - Blauwendraat, Cornelis

AU - Singleton, Andrew B.

AU - Tan, MMX

AU - Iwaki, Hirotaka

AU - Morris, Huw R.

AU - Gatto, Emilia M.

AU - Kauffman, Marcelo

AU - Khachatryan, Samson

AU - Tavadyan, Zaruhi

AU - Shepherd, Claire E.

AU - Hunter, Julie

AU - Kumar, Kishore

AU - Ellis, Melina

AU - Rentería, Miguel E.

AU - Koks, Sulev

AU - Zimprich, Alexander

AU - Schumacher-Schuh, Artur F.

AU - Rieder, Carlos

AU - Awad, Paula Saffie

AU - Tumas, Vitor

AU - Camargos, Sarah

AU - Fon, EA

AU - Monchi, Oury

AU - Fon, T

AU - Galleguillos, Benjamin Pizarro

AU - Miranda, Marcelo

AU - Bustamante, Maria Leonor

AU - Olguin, Patricio

AU - Chana, Pedro

AU - Tang, Beisha

AU - Shang, Huifang

AU - Guo, Jifeng

AU - Chan, P

AU - Luo, Wei

AU - Arboleda, Gonzalo

AU - Orozco, Jorge

AU - del, Rio MJ

AU - Hernandez, A

AU - Salama, Mohamed

AU - Kamel, Walaa A.

AU - Zewde, Yared Z.

AU - Brice, Alexis

AU - Corvol, Jean Christophe

AU - Westenberger, Ana

AU - Illarionova, Anastasia

AU - Mollenhauer, Brit

AU - Klein, Christine

AU - Vollstedt, Eva Juliane

AU - Hopfner, Franziska

AU - Höglinger, Günter

AU - Madoev, Harutyun

AU - Trinh, Joanne

AU - Junker, Johanna

AU - Lohmann, Katja

AU - Lange, Lara M.

AU - Sharma, Manu

AU - Groppa, Sergiu

AU - Gasser, Thomas

AU - Fang, Zih Hua

AU - Akpalu, Albert

AU - Xiromerisiou, Georgia

AU - Hadjigorgiou, Georgios

AU - Dagklis, Ioannis

AU - Tarnanas, Ioannis

AU - Stefanis, Leonidas

AU - Stamelou, Maria

AU - Dadiotis, Efthymios

AU - Medina, Alex

AU - Chan, GH-F

AU - Ip, Nancy

AU - Cheung, Nelson Yuk Fai

AU - Carroll, Camille

PY - 2023/9/12

Y1 - 2023/9/12

N2 - The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

AB - The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

UR - https://pearl.plymouth.ac.uk/pms-research/1680/

U2 - 10.1038/s41531-023-00533-w

DO - 10.1038/s41531-023-00533-w

M3 - Article

SN - 2373-8057

VL - 9

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

IS - 1

ER -

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

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