Current considerations for the effective safety evaluation of drugs in vitro.

Jinsheng Xu; Simon K. Jackson

doi:10.2174/138955709788452577

Current considerations for the effective safety evaluation of drugs in vitro.

Jinsheng Xu^*, Simon K. Jackson

^*Corresponding author for this work

School of Biomedical Sciences

University of the West of England

Research output: Contribution to journal › Article › peer-review

Abstract

As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.

Original language	English
Pages (from-to)	861-868
Number of pages	0
Journal	Mini Rev Med Chem
Volume	9
Issue number	7
DOIs	https://doi.org/10.2174/138955709788452577
Publication status	Published - Jun 2009

Keywords

Animals
Drug Evaluation
Preclinical
Drug-Related Side Effects and Adverse Reactions
Endpoint Determination
Humans
Quality Control
Reference Standards
Risk Assessment

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title = "Current considerations for the effective safety evaluation of drugs in vitro.",

abstract = "As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.",

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author = "Jinsheng Xu and Jackson, {Simon K.}",

year = "2009",

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AU - Jackson, Simon K.

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AB - As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.

KW - Animals

KW - Drug Evaluation

KW - Preclinical

KW - Drug-Related Side Effects and Adverse Reactions

KW - Endpoint Determination

KW - Humans

KW - Quality Control

KW - Reference Standards

KW - Risk Assessment

U2 - 10.2174/138955709788452577

DO - 10.2174/138955709788452577

M3 - Article

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SP - 861

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JO - Mini Rev Med Chem

JF - Mini Rev Med Chem

IS - 7

ER -

Current considerations for the effective safety evaluation of drugs in vitro.

Abstract

Keywords

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