Curare (d-Tubocurarine)

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Curare is a plant extract obtained from Strychnos toxifera, Chondrodendron tomentosum, and related species indigenous to South America. The principal active constituent is (+)-tubocurarine (d-Tubocurarine). When parentally administered, d-Tubocurarine is a potent reversible competitive antagonist at nicotinic acetylcholine receptors on the motor end plate of the neuromuscular junction, causing rapid flaccid paralysis of skeletal muscle. Reversal of paralysis may be hastened via the administration of cholinesterase inhibitors, prolonging the availability of naturally produced acetylcholine.

Original languageEnglish
Title of host publicationEncyclopedia of Toxicology
Pages353-357
Number of pages0
Volume3
ISBN (Electronic)9780128243152
DOIs
Publication statusPublished - 2024

ASJC Scopus subject areas

  • General Medicine

Keywords

  • Acetylcholine
  • Arrow poison
  • Benzylisoquinoline
  • Curare alkaloid
  • Isoquinoline
  • Neuromuscular blocker
  • Neurotoxicity
  • Neurotoxin
  • Nicotinic antagonist
  • Non-depolarizing agent
  • Quaternary ammonium compound

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