Collagen gel as a 3D in vitro tissue model for ameloblastoma studies

C Raison; S Porter; S Fedele; MP Lewis; V Salih

Collagen gel as a 3D in vitro tissue model for ameloblastoma studies

C Raison, S Porter, S Fedele, MP Lewis, V Salih

Peninsula Dental School

Research output: Contribution to journal › Conference proceedings published in a journal › peer-review

Abstract

Ameloblastoma is a rare locally invasive epithelial odontogenic tumour of the jaw which can cause significant and debilitating bone destruction. In vitro studies of ameloblastoma are sparse in the literature, and little is known regarding patterns of ameloblastoma cell growth and invasion, as well as relevant gene and protein expression. This study aims to (i) use plastic-compressed collagen gels as a robust and relevant biomimetic to culture ameloblastoma cells in a 3D in vitro tissue model [1] and (ii) perform histology, immunohistochemistry (IHC) and gene expression assays to characterise tissue remodelling, cell growth and invasiveness.

Original language	English
Pages (from-to)	86-86
Number of pages	0
Journal	European Cells and Materials
Volume	22
Issue number	0
Publication status	Published - Jul 2011
Event	Tissue and Cell Engineering Society Meeting - Duration: 28 Jul 2010 → …

Cite this

@article{666927b3bc15428e8b3fddfe31832280,

title = "Collagen gel as a 3D in vitro tissue model for ameloblastoma studies",

abstract = "Ameloblastoma is a rare locally invasive epithelial odontogenic tumour of the jaw which can cause significant and debilitating bone destruction. In vitro studies of ameloblastoma are sparse in the literature, and little is known regarding patterns of ameloblastoma cell growth and invasion, as well as relevant gene and protein expression. This study aims to (i) use plastic-compressed collagen gels as a robust and relevant biomimetic to culture ameloblastoma cells in a 3D in vitro tissue model [1] and (ii) perform histology, immunohistochemistry (IHC) and gene expression assays to characterise tissue remodelling, cell growth and invasiveness.",

author = "C Raison and S Porter and S Fedele and MP Lewis and V Salih",

year = "2011",

month = jul,

language = "English",

volume = "22",

pages = "86--86",

journal = "European Cells and Materials",

issn = "1473-2262",

publisher = "AO Research Institute",

number = "0",

note = "Tissue and Cell Engineering Society Meeting ; Conference date: 28-07-2010",

}

TY - JOUR

T1 - Collagen gel as a 3D in vitro tissue model for ameloblastoma studies

AU - Raison, C

AU - Porter, S

AU - Fedele, S

AU - Lewis, MP

AU - Salih, V

PY - 2011/7

Y1 - 2011/7

N2 - Ameloblastoma is a rare locally invasive epithelial odontogenic tumour of the jaw which can cause significant and debilitating bone destruction. In vitro studies of ameloblastoma are sparse in the literature, and little is known regarding patterns of ameloblastoma cell growth and invasion, as well as relevant gene and protein expression. This study aims to (i) use plastic-compressed collagen gels as a robust and relevant biomimetic to culture ameloblastoma cells in a 3D in vitro tissue model [1] and (ii) perform histology, immunohistochemistry (IHC) and gene expression assays to characterise tissue remodelling, cell growth and invasiveness.

AB - Ameloblastoma is a rare locally invasive epithelial odontogenic tumour of the jaw which can cause significant and debilitating bone destruction. In vitro studies of ameloblastoma are sparse in the literature, and little is known regarding patterns of ameloblastoma cell growth and invasion, as well as relevant gene and protein expression. This study aims to (i) use plastic-compressed collagen gels as a robust and relevant biomimetic to culture ameloblastoma cells in a 3D in vitro tissue model [1] and (ii) perform histology, immunohistochemistry (IHC) and gene expression assays to characterise tissue remodelling, cell growth and invasiveness.

M3 - Conference proceedings published in a journal

SN - 1473-2262

VL - 22

SP - 86

EP - 86

JO - European Cells and Materials

JF - European Cells and Materials

IS - 0

T2 - Tissue and Cell Engineering Society Meeting

Y2 - 28 July 2010

ER -

Collagen gel as a 3D in vitro tissue model for ameloblastoma studies

Abstract

Fingerprint

Cite this