Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms.

P Mitchell; R Mitchell; AJ Moody; IC West; H Baum; JM Wrigglesworth

doi:10.1016/0014-5793(85)80863-2

Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms.

P Mitchell, R Mitchell, AJ Moody, IC West, H Baum, JM Wrigglesworth

School of Biological and Marine Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Using the principle of specific vectorial ligand conduction, we outline directly coupled protonmotive O loop and O cycle mechanisms of cytochrome oxidase action that are analogous to protonmotive Q loop and Q cycle mechanisms of QH2 dehydrogenase action. We discuss these directly coupled mechanisms in the light of available experimental knowledge, and suggest that they may stimulate useful new research initiatives designed to elucidate the osmochemistry of protonmotive oxygen reduction in cytochrome oxidase.

Original language	English
Pages (from-to)	1-7
Number of pages	0
Journal	FEBS Lett
Volume	188
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(85)80863-2
Publication status	Published - 19 Aug 1985

Keywords

Biological Transport
Chemical Phenomena
Chemistry
Copper
Electron Transport
Electron Transport Complex IV
Hydrogen Peroxide
Hydrogen-Ion Concentration
Ion Channels
Membrane Potentials
Osmosis
Oxidation-Reduction
Oxygen
Protons
Superoxides

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10.1016/0014-5793(85)80863-2

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title = "Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms.",

abstract = "Using the principle of specific vectorial ligand conduction, we outline directly coupled protonmotive O loop and O cycle mechanisms of cytochrome oxidase action that are analogous to protonmotive Q loop and Q cycle mechanisms of QH2 dehydrogenase action. We discuss these directly coupled mechanisms in the light of available experimental knowledge, and suggest that they may stimulate useful new research initiatives designed to elucidate the osmochemistry of protonmotive oxygen reduction in cytochrome oxidase.",

keywords = "Biological Transport, Chemical Phenomena, Chemistry, Copper, Electron Transport, Electron Transport Complex IV, Hydrogen Peroxide, Hydrogen-Ion Concentration, Ion Channels, Membrane Potentials, Osmosis, Oxidation-Reduction, Oxygen, Protons, Superoxides",

author = "P Mitchell and R Mitchell and AJ Moody and IC West and H Baum and JM Wrigglesworth",

year = "1985",

month = aug,

day = "19",

doi = "10.1016/0014-5793(85)80863-2",

language = "English",

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T1 - Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms.

AU - Mitchell, P

AU - Mitchell, R

AU - Moody, AJ

AU - West, IC

AU - Baum, H

AU - Wrigglesworth, JM

PY - 1985/8/19

Y1 - 1985/8/19

N2 - Using the principle of specific vectorial ligand conduction, we outline directly coupled protonmotive O loop and O cycle mechanisms of cytochrome oxidase action that are analogous to protonmotive Q loop and Q cycle mechanisms of QH2 dehydrogenase action. We discuss these directly coupled mechanisms in the light of available experimental knowledge, and suggest that they may stimulate useful new research initiatives designed to elucidate the osmochemistry of protonmotive oxygen reduction in cytochrome oxidase.

AB - Using the principle of specific vectorial ligand conduction, we outline directly coupled protonmotive O loop and O cycle mechanisms of cytochrome oxidase action that are analogous to protonmotive Q loop and Q cycle mechanisms of QH2 dehydrogenase action. We discuss these directly coupled mechanisms in the light of available experimental knowledge, and suggest that they may stimulate useful new research initiatives designed to elucidate the osmochemistry of protonmotive oxygen reduction in cytochrome oxidase.

KW - Biological Transport

KW - Chemical Phenomena

KW - Chemistry

KW - Copper

KW - Electron Transport

KW - Electron Transport Complex IV

KW - Hydrogen Peroxide

KW - Hydrogen-Ion Concentration

KW - Ion Channels

KW - Membrane Potentials

KW - Osmosis

KW - Oxidation-Reduction

KW - Oxygen

KW - Protons

KW - Superoxides

U2 - 10.1016/0014-5793(85)80863-2

DO - 10.1016/0014-5793(85)80863-2

M3 - Article

SN - 0014-5793

VL - 188

SP - 1

EP - 7

JO - FEBS Lett

JF - FEBS Lett

IS - 1

ER -

Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms.

Abstract

Keywords

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