Abstract
Changes in the lipids of tissues from mice infected with bacille Calmette-Guérin (BCG) have been detected by gas-liquid chromatography. Infection with BCG resulted in (1) an increase in the polyunsaturated to saturated fatty acid ratio of phospholipids and (2) a decrease in the total triacylglycerol fatty acid content of spleen, liver and peritoneal macrophages. The alteration in fatty acid composition was significant in the phosphatidylethanolamine fraction of the phospholipids. The relation of these findings to an increased sensitivity to bacterial endotoxins is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 435-441 |
| Number of pages | 0 |
| Journal | Br J Exp Pathol |
| Volume | 70 |
| Issue number | 4 |
| Publication status | Published - Aug 1989 |
Keywords
- Animals
- Chromatography
- Gas
- Fatty Acids
- Liver
- Macrophages
- Mice
- Mycobacterium bovis
- Phospholipids
- Spleen
- Triglycerides
- Tuberculosis