Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases

GM Ramdharry; A Wallace; P Hennis; E Dewar; M Dudziec; K Jones; A Pietrusz; MM Reilly; MG Hanna

doi:10.1002/mus.27423

Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases

GM Ramdharry, A Wallace, P Hennis, E Dewar, M Dudziec, K Jones, A Pietrusz, MM Reilly, MG Hanna

School of Health Professions

Research output: Contribution to journal › Article › peer-review

Abstract

AbstractIntroduction/AimsAerobic deconditioning, due to lower levels of physical activity, could impact independence for people with neuromuscular conditions. We report the maximal cardiopulmonary response in a cohort of people with Charcot Marie Tooth disease type 1A (CMT 1A) and inclusion body myositis (IBM). We also explored potential predictors of aerobic capacity with measures of physical impairment and functional performance.MethodsParticipants underwent maximal cardiopulmonary exercise testing (CPET) using a semi‐recumbent cycle ergometer. Data were analyzed to determine the peak O2 consumption (VO2 peak), anaerobic threshold (AT), maximum heart rate (MHR), ventilatory equivalent for CO2 slope (VE/VCO2), and respiratory exchange ratio (RER). Impairment, functional and patient reported measures were also recorded. Predicted CPET variables were calculated based on published normative data for age, gender, and weight.ResultsTwenty‐two people with CMT and 17 people with IBM were recruited. Both groups showed significantly lower VO2 peak, MHR, AT, and VE/VCO2. The CMT group overall performed better than the IBM group, with significantly higher VO2 peak, MHR, and AT, but lower VE/VCO2. Linear regression analysis demonstrated that VO2 peak was related to body fat percentage and 6‐min walk distance for both groups, and steps per day for the IBM group.DiscussionLower than predicted CPET variables were observed that were not explained by cardiopulmonary limitations or reduced effort, implicating peripheral factors in limiting the cycling task. Regression analysis implied prediction of VO2 peak by body fat percentage and 6‐min walk distance. Six‐minute walk distance could be a potential proxy measure of cardiopulmonary fitness.

Original language	English
Pages (from-to)	683-690
Number of pages	0
Journal	Muscle & Nerve
Volume	64
Issue number	6
Early online date	6 Oct 2021
DOIs	https://doi.org/10.1002/mus.27423
Publication status	Published - Dec 2021

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10.1002/mus.27423

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title = "Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases",

abstract = "AbstractIntroduction/AimsAerobic deconditioning, due to lower levels of physical activity, could impact independence for people with neuromuscular conditions. We report the maximal cardiopulmonary response in a cohort of people with Charcot Marie Tooth disease type 1A (CMT 1A) and inclusion body myositis (IBM). We also explored potential predictors of aerobic capacity with measures of physical impairment and functional performance.MethodsParticipants underwent maximal cardiopulmonary exercise testing (CPET) using a semi‐recumbent cycle ergometer. Data were analyzed to determine the peak O2 consumption (VO2 peak), anaerobic threshold (AT), maximum heart rate (MHR), ventilatory equivalent for CO2 slope (VE/VCO2), and respiratory exchange ratio (RER). Impairment, functional and patient reported measures were also recorded. Predicted CPET variables were calculated based on published normative data for age, gender, and weight.ResultsTwenty‐two people with CMT and 17 people with IBM were recruited. Both groups showed significantly lower VO2 peak, MHR, AT, and VE/VCO2. The CMT group overall performed better than the IBM group, with significantly higher VO2 peak, MHR, and AT, but lower VE/VCO2. Linear regression analysis demonstrated that VO2 peak was related to body fat percentage and 6‐min walk distance for both groups, and steps per day for the IBM group.DiscussionLower than predicted CPET variables were observed that were not explained by cardiopulmonary limitations or reduced effort, implicating peripheral factors in limiting the cycling task. Regression analysis implied prediction of VO2 peak by body fat percentage and 6‐min walk distance. Six‐minute walk distance could be a potential proxy measure of cardiopulmonary fitness.",

author = "GM Ramdharry and A Wallace and P Hennis and E Dewar and M Dudziec and K Jones and A Pietrusz and MM Reilly and MG Hanna",

year = "2021",

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doi = "10.1002/mus.27423",

language = "English",

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pages = "683--690",

journal = "Muscle & Nerve",

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T1 - Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases

AU - Ramdharry, GM

AU - Wallace, A

AU - Hennis, P

AU - Dewar, E

AU - Dudziec, M

AU - Jones, K

AU - Pietrusz, A

AU - Reilly, MM

AU - Hanna, MG

PY - 2021/12

Y1 - 2021/12

N2 - AbstractIntroduction/AimsAerobic deconditioning, due to lower levels of physical activity, could impact independence for people with neuromuscular conditions. We report the maximal cardiopulmonary response in a cohort of people with Charcot Marie Tooth disease type 1A (CMT 1A) and inclusion body myositis (IBM). We also explored potential predictors of aerobic capacity with measures of physical impairment and functional performance.MethodsParticipants underwent maximal cardiopulmonary exercise testing (CPET) using a semi‐recumbent cycle ergometer. Data were analyzed to determine the peak O2 consumption (VO2 peak), anaerobic threshold (AT), maximum heart rate (MHR), ventilatory equivalent for CO2 slope (VE/VCO2), and respiratory exchange ratio (RER). Impairment, functional and patient reported measures were also recorded. Predicted CPET variables were calculated based on published normative data for age, gender, and weight.ResultsTwenty‐two people with CMT and 17 people with IBM were recruited. Both groups showed significantly lower VO2 peak, MHR, AT, and VE/VCO2. The CMT group overall performed better than the IBM group, with significantly higher VO2 peak, MHR, and AT, but lower VE/VCO2. Linear regression analysis demonstrated that VO2 peak was related to body fat percentage and 6‐min walk distance for both groups, and steps per day for the IBM group.DiscussionLower than predicted CPET variables were observed that were not explained by cardiopulmonary limitations or reduced effort, implicating peripheral factors in limiting the cycling task. Regression analysis implied prediction of VO2 peak by body fat percentage and 6‐min walk distance. Six‐minute walk distance could be a potential proxy measure of cardiopulmonary fitness.

AB - AbstractIntroduction/AimsAerobic deconditioning, due to lower levels of physical activity, could impact independence for people with neuromuscular conditions. We report the maximal cardiopulmonary response in a cohort of people with Charcot Marie Tooth disease type 1A (CMT 1A) and inclusion body myositis (IBM). We also explored potential predictors of aerobic capacity with measures of physical impairment and functional performance.MethodsParticipants underwent maximal cardiopulmonary exercise testing (CPET) using a semi‐recumbent cycle ergometer. Data were analyzed to determine the peak O2 consumption (VO2 peak), anaerobic threshold (AT), maximum heart rate (MHR), ventilatory equivalent for CO2 slope (VE/VCO2), and respiratory exchange ratio (RER). Impairment, functional and patient reported measures were also recorded. Predicted CPET variables were calculated based on published normative data for age, gender, and weight.ResultsTwenty‐two people with CMT and 17 people with IBM were recruited. Both groups showed significantly lower VO2 peak, MHR, AT, and VE/VCO2. The CMT group overall performed better than the IBM group, with significantly higher VO2 peak, MHR, and AT, but lower VE/VCO2. Linear regression analysis demonstrated that VO2 peak was related to body fat percentage and 6‐min walk distance for both groups, and steps per day for the IBM group.DiscussionLower than predicted CPET variables were observed that were not explained by cardiopulmonary limitations or reduced effort, implicating peripheral factors in limiting the cycling task. Regression analysis implied prediction of VO2 peak by body fat percentage and 6‐min walk distance. Six‐minute walk distance could be a potential proxy measure of cardiopulmonary fitness.

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DO - 10.1002/mus.27423

M3 - Article

SN - 0148-639X

VL - 64

SP - 683

EP - 690

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 6

ER -

Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases

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