Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA

Assis LJ de; LP Silva; O Bayram; P Dowling; O Kniemeyer; T Krüger; AA Brakhage; Yingying Chen; L Dong; K Tan; KH Wong; LNA Ries; GH Goldman

Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA

Assis LJ de
, LP Silva
, O Bayram
, P Dowling
, O Kniemeyer
, T Krüger
, AA Brakhage
, Yingying Chen
, L Dong
, K Tan
, KH Wong
, LNA Ries
, GH Goldman

University of Macau

Research output: Contribution to journal › Article › peer-review

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Abstract

In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans CreA, and subsequently, the two newly identified sites S268 and T308, the previously identified but uncharacterized site S262, and the previously characterized site S319 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was characterized.

Original language	English
Journal	mBio
Volume	12
Issue number	1
Publication status	Published - 23 Feb 2021

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Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreAFinal published version, 3.59 MB

https://doi.org/10.1128/mBio.03146-20

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title = "Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA",

abstract = "In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans CreA, and subsequently, the two newly identified sites S268 and T308, the previously identified but uncharacterized site S262, and the previously characterized site S319 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was characterized. ",

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month = feb,

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T1 - Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA

AU - de, Assis LJ

AU - Silva, LP

AU - Bayram, O

AU - Dowling, P

AU - Kniemeyer, O

AU - Krüger, T

AU - Brakhage, AA

AU - Chen, Yingying

AU - Dong, L

AU - Tan, K

AU - Wong, KH

AU - Ries, LNA

AU - Goldman, GH

PY - 2021/2/23

Y1 - 2021/2/23

N2 - In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans CreA, and subsequently, the two newly identified sites S268 and T308, the previously identified but uncharacterized site S262, and the previously characterized site S319 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was characterized.

AB - In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans CreA, and subsequently, the two newly identified sites S268 and T308, the previously identified but uncharacterized site S262, and the previously characterized site S319 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was characterized.

UR - https://pearl.plymouth.ac.uk/pms-research/1288/

M3 - Article

SN - 2161-2129

VL - 12

JO - mBio

JF - mBio

IS - 1

ER -

Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA

Abstract

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