TY - JOUR
T1 - Burkitt'S lymphoma in pregnancy with bilateral breast involvement
T2 - Case report with review of the literature
AU - Savvari, Paraskevi
AU - Matsouka, Chara
AU - Barbaroussi, Despoina
AU - Christoulas, Dimitrios
AU - Nikitas, Nikitas
AU - Dimopoulos, Meletios A.
AU - Papadimitriou, Christos A.
PY - 2010/9
Y1 - 2010/9
N2 - Background: Burkitt's lymphoma (BL) in pregnancy presenting with breast involvement is a rare clinical entity, and only 13 cases have been reported so far. Case Report: We describe the case of a 28-year-old postpartum woman who presented with markedly enlarged breasts caused by BL. She was treated with 8 cycles of the CALGB 10002 regimen, as well as with irradiation to both breasts. After achieving a complete objective response, the patient received consolidation with high dose BEAM followed by autologous stem cell transplantation. 20 months after the initial diagnosis, our patient remains alive and relapse-free. Data extracted from the published case reports include information regarding demographic details, type of treatment, sites of disease, and survival. The clinical outcome of the reviewed cases was very unfavorable. Conclusions: BL affecting breasts during pregnancy or lactation is a rare entity that requires a prompt diagnosis and an aggressive therapeutic approach.
AB - Background: Burkitt's lymphoma (BL) in pregnancy presenting with breast involvement is a rare clinical entity, and only 13 cases have been reported so far. Case Report: We describe the case of a 28-year-old postpartum woman who presented with markedly enlarged breasts caused by BL. She was treated with 8 cycles of the CALGB 10002 regimen, as well as with irradiation to both breasts. After achieving a complete objective response, the patient received consolidation with high dose BEAM followed by autologous stem cell transplantation. 20 months after the initial diagnosis, our patient remains alive and relapse-free. Data extracted from the published case reports include information regarding demographic details, type of treatment, sites of disease, and survival. The clinical outcome of the reviewed cases was very unfavorable. Conclusions: BL affecting breasts during pregnancy or lactation is a rare entity that requires a prompt diagnosis and an aggressive therapeutic approach.
KW - Breast
KW - Burkitt's lymphoma
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=77956624126&partnerID=8YFLogxK
U2 - 10.1159/000317344
DO - 10.1159/000317344
M3 - Article
C2 - 20838063
AN - SCOPUS:77956624126
SN - 0378-584X
VL - 33
SP - 461
EP - 464
JO - Onkologie
JF - Onkologie
IS - 8-9
ER -