British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy

S. Grigoriadou; R. Clubbe; T. Garcez; A. Huissoon; D. Grosse-Kreul; S. Jolles; K. Henderson; J. Edmonds; D. Lowe; C. Bethune

doi:10.1093/cei/uxac070

British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy

S. Grigoriadou^*, R. Clubbe, T. Garcez, A. Huissoon, D. Grosse-Kreul, S. Jolles, K. Henderson, J. Edmonds, D. Lowe, C. Bethune

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Currently, there is no guideline to support the use of immunoglobulin replacement therapy (IgRT) in primary and secondary immunodeficiency disorders in UK. The UK Primary Immunodeficiency Network (UK-PIN) and the British Society of Immunology (BSI) joined forces to address this need. Given the paucity of evidence, a modified Delphi approach was used covering statements for the initiation, monitoring, discontinuation of IgRT as well as home therapy programme. A group of six consultant immunologists and three nurse specialists created the statements, reviewed responses and feedback and agreed on final recommendations. This guideline includes 22 statements for initiation, 22 statements for monitoring, 11 statement for home therapy, and 19 statements for discontinuation of IgRT. Further areas of research are proposed to improve future delivery of care.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	Clinical and Experimental Immunology
Volume	210
Issue number	1
DOIs	https://doi.org/10.1093/cei/uxac070
Publication status	Published - Oct 2022
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Keywords

antibodies
human
immunodeficiency disorders
immunoglobulin

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10.1093/cei/uxac070

Cite this

Grigoriadou, S., Clubbe, R., Garcez, T., Huissoon, A., Grosse-Kreul, D., Jolles, S., Henderson, K., Edmonds, J., Lowe, D., & Bethune, C. (2022). British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy. Clinical and Experimental Immunology, 210(1), 1-13. https://doi.org/10.1093/cei/uxac070

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title = "British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy",

abstract = "Currently, there is no guideline to support the use of immunoglobulin replacement therapy (IgRT) in primary and secondary immunodeficiency disorders in UK. The UK Primary Immunodeficiency Network (UK-PIN) and the British Society of Immunology (BSI) joined forces to address this need. Given the paucity of evidence, a modified Delphi approach was used covering statements for the initiation, monitoring, discontinuation of IgRT as well as home therapy programme. A group of six consultant immunologists and three nurse specialists created the statements, reviewed responses and feedback and agreed on final recommendations. This guideline includes 22 statements for initiation, 22 statements for monitoring, 11 statement for home therapy, and 19 statements for discontinuation of IgRT. Further areas of research are proposed to improve future delivery of care.",

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author = "S. Grigoriadou and R. Clubbe and T. Garcez and A. Huissoon and D. Grosse-Kreul and S. Jolles and K. Henderson and J. Edmonds and D. Lowe and C. Bethune",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of the British Society for Immunology.",

year = "2022",

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doi = "10.1093/cei/uxac070",

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Grigoriadou, S, Clubbe, R, Garcez, T, Huissoon, A, Grosse-Kreul, D, Jolles, S, Henderson, K, Edmonds, J, Lowe, D & Bethune, C 2022, 'British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy', Clinical and Experimental Immunology, vol. 210, no. 1, pp. 1-13. https://doi.org/10.1093/cei/uxac070

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AU - Grigoriadou, S.

AU - Clubbe, R.

AU - Garcez, T.

AU - Huissoon, A.

AU - Grosse-Kreul, D.

AU - Jolles, S.

AU - Henderson, K.

AU - Edmonds, J.

AU - Lowe, D.

AU - Bethune, C.

PY - 2022/10

Y1 - 2022/10

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AB - Currently, there is no guideline to support the use of immunoglobulin replacement therapy (IgRT) in primary and secondary immunodeficiency disorders in UK. The UK Primary Immunodeficiency Network (UK-PIN) and the British Society of Immunology (BSI) joined forces to address this need. Given the paucity of evidence, a modified Delphi approach was used covering statements for the initiation, monitoring, discontinuation of IgRT as well as home therapy programme. A group of six consultant immunologists and three nurse specialists created the statements, reviewed responses and feedback and agreed on final recommendations. This guideline includes 22 statements for initiation, 22 statements for monitoring, 11 statement for home therapy, and 19 statements for discontinuation of IgRT. Further areas of research are proposed to improve future delivery of care.

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KW - immunodeficiency disorders

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British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy

Abstract

ASJC Scopus subject areas

Keywords

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