Abstract
Introduction: Little information exists regarding the detection of early coronary heart disease protein biomarkers. The aim of this study was to investigate several potential candidates. Methods: Systematic review was carried out followed by meta-analysis. Results: The standardized mean difference (95% confidence intervals) for each comparison was: Troponins 2.31 (1.18, 3.4), iL-6 1.3 (0.8, 1.81), fibrinogen 1.55 (1.16, 1.94), NT-proBNP 1.05 (0.72, 1.38), lipoprotein a 0.75 (0.48, 1.03) osteoprotegerin 0.92 (0.23, 1.62), VCAM-1 1.53 (0.87, 2.18), pentraxin 3 0.87 (−0.13, 1.87), PAI-1 2.51 (−0.65, 5.66) MMP9 1.25 (0.36, 2.14), MCP-1 1.99 (1.12, 2.85) and adiponectin −1.11 (−1.49, −0.73). Conclusion: Multiple biomarkers that could potentially be used for the early detection of coronary heart disease were identified.
| Original language | English |
|---|---|
| Pages (from-to) | 39-46 |
| Number of pages | 8 |
| Journal | Future Cardiology |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 15 Jan 2025 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Molecular Medicine
- Cardiology and Cardiovascular Medicine
Keywords
- Biomarkers
- coronary artery disease
- diagnostic point-of-care sensors
- graphene field-effect transistors; meta-analysis
- Humans
- Biomarkers/blood
- Coronary Artery Disease/blood
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