TY - JOUR
T1 - Are Survival Outcomes Different for Young and Old Patients with Oral and Oropharyngeal Squamous Cell Carcinoma? A Systematic Review and Meta-Analysis
AU - Panda, Swagatika
AU - Mohanty, Neeta
AU - Panda, Saurav
AU - Mishra, Lora
AU - Gopinath, Divya
AU - Sahoo, Alkananda
AU - Nagraj, Sumanth Kumbargere
AU - Lapinska, Barbara
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4/8
Y1 - 2022/4/8
N2 - This systematic review and meta-analysis aims to address whether age can be a determinant of overall survival (OS), disease-free survival (DFS), recurrence, distant metastasis (DM) and second primary (SP) in surgically treated oral and oropharyngeal squamous cell carcinoma (OOPSCC). A total of 4981 cases and 44254 controls from 25 comparative observational studies were included in the analysis. A significantly better OS (matched subgroup analysis: OR 1.64; 95% CI 1.31–2.04, overall analysis: OR 1.48; 95% CI 1.09–2.01) was observed in young patients compared to older adults, with heterogeneity ranging from moderate to severe. Worse DFS (unmatched subgroup analysis OR 0.43; 95% CI 0.27–0.68) was observed in young patients compared to older adults with minimal to moderate heterogeneity. The frequency of recurrence (OR 1.49; 95% CI 1.10–2.02) and DM (OR 1.83; 95% CI 1.10–3.03) was significantly higher in the young patients, as found in unmatched and matched subgroup analysis, with the least heterogeneities. Young age can be considered as an independent prognostic factor for recurrence and distant metastases in OOP-SCC. Larger and methodologically robust observational studies with longer follow-up are needed to establish the definitive role of age as an independent prognostic factor on OS and DFS in OOPSCC.
AB - This systematic review and meta-analysis aims to address whether age can be a determinant of overall survival (OS), disease-free survival (DFS), recurrence, distant metastasis (DM) and second primary (SP) in surgically treated oral and oropharyngeal squamous cell carcinoma (OOPSCC). A total of 4981 cases and 44254 controls from 25 comparative observational studies were included in the analysis. A significantly better OS (matched subgroup analysis: OR 1.64; 95% CI 1.31–2.04, overall analysis: OR 1.48; 95% CI 1.09–2.01) was observed in young patients compared to older adults, with heterogeneity ranging from moderate to severe. Worse DFS (unmatched subgroup analysis OR 0.43; 95% CI 0.27–0.68) was observed in young patients compared to older adults with minimal to moderate heterogeneity. The frequency of recurrence (OR 1.49; 95% CI 1.10–2.02) and DM (OR 1.83; 95% CI 1.10–3.03) was significantly higher in the young patients, as found in unmatched and matched subgroup analysis, with the least heterogeneities. Young age can be considered as an independent prognostic factor for recurrence and distant metastases in OOP-SCC. Larger and methodologically robust observational studies with longer follow-up are needed to establish the definitive role of age as an independent prognostic factor on OS and DFS in OOPSCC.
KW - disease-free survival
KW - distant metastasis
KW - oral carcinoma
KW - oropharyngeal squamous cell carcinoma
KW - overall survival
KW - recurrence
KW - second primary
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85127645090&partnerID=8YFLogxK
UR - https://pearl.plymouth.ac.uk/context/pds-research/article/1223/viewcontent/Are_Survival_Outcomes_Different_for_Young_and_Old_Patients_with_Oral_and_Oropharyngeal_Squamous_Cell_Carcinoma_A_Systematic_.pdf
U2 - 10.3390/cancers14081886
DO - 10.3390/cancers14081886
M3 - Review article
AN - SCOPUS:85127645090
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 8
M1 - 1886
ER -
