Anhedonia reduction correlates with increased ventral caudate connectivity with superior frontal gyrus in depression.

Xinhua Yang; Jia Huang; Matthew E. Roser; X Guangrong

doi:10.1016/j.jpsychires.2022.04.030

Anhedonia reduction correlates with increased ventral caudate connectivity with superior frontal gyrus in depression.

Xinhua Yang^*
, Jia Huang
, Matthew E. Roser
, X Guangrong

^*Corresponding author for this work

Shanghai Changning Mental Health Center
University of Plymouth
CAS - Institute of Psychology
University of Chinese Academy of Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

This study was to investigate the relationship between the ventral caudate connectivity and anhedonia. Nineteen depressed patients and 16 healthy controls participated in two identical functional magnetic resonance imaging scans during a 1-year period to determine the resting-state functional connectivity changes using a seed-based approach. Patients showed increased left ventral caudate functional connectivity with superior frontal gyrus over time and the increased connectivity was associated with anhedonia improvement. None of these associations were observed in healthy controls. The findings suggest that left ventral caudate may serve as a potential target to improve the severity of anhedonia.

Original language	English
Pages (from-to)	286-290
Journal	Journal of Psychiatric Research
Volume	151
Early online date	28 Apr 2022
DOIs	https://doi.org/10.1016/j.jpsychires.2022.04.030
Publication status	Published - 4 May 2022

Keywords

Anhedonia
Ventral caudate
Superior frontal gyrus

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10.1016/j.jpsychires.2022.04.030

Yang Huang Roser Xie JoPsychRes manuscriptAccepted author manuscript, 448 KB

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title = "Anhedonia reduction correlates with increased ventral caudate connectivity with superior frontal gyrus in depression.",

abstract = "This study was to investigate the relationship between the ventral caudate connectivity and anhedonia. Nineteen depressed patients and 16 healthy controls participated in two identical functional magnetic resonance imaging scans during a 1-year period to determine the resting-state functional connectivity changes using a seed-based approach. Patients showed increased left ventral caudate functional connectivity with superior frontal gyrus over time and the increased connectivity was associated with anhedonia improvement. None of these associations were observed in healthy controls. The findings suggest that left ventral caudate may serve as a potential target to improve the severity of anhedonia.",

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AU - Yang, Xinhua

AU - Huang, Jia

AU - Roser, Matthew E.

AU - Guangrong, X

PY - 2022/5/4

Y1 - 2022/5/4

N2 - This study was to investigate the relationship between the ventral caudate connectivity and anhedonia. Nineteen depressed patients and 16 healthy controls participated in two identical functional magnetic resonance imaging scans during a 1-year period to determine the resting-state functional connectivity changes using a seed-based approach. Patients showed increased left ventral caudate functional connectivity with superior frontal gyrus over time and the increased connectivity was associated with anhedonia improvement. None of these associations were observed in healthy controls. The findings suggest that left ventral caudate may serve as a potential target to improve the severity of anhedonia.

AB - This study was to investigate the relationship between the ventral caudate connectivity and anhedonia. Nineteen depressed patients and 16 healthy controls participated in two identical functional magnetic resonance imaging scans during a 1-year period to determine the resting-state functional connectivity changes using a seed-based approach. Patients showed increased left ventral caudate functional connectivity with superior frontal gyrus over time and the increased connectivity was associated with anhedonia improvement. None of these associations were observed in healthy controls. The findings suggest that left ventral caudate may serve as a potential target to improve the severity of anhedonia.

KW - Anhedonia

KW - Ventral caudate

KW - Superior frontal gyrus

UR - https://pearl.plymouth.ac.uk/psy-research/520/

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DO - 10.1016/j.jpsychires.2022.04.030

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EP - 290

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

ER -

Anhedonia reduction correlates with increased ventral caudate connectivity with superior frontal gyrus in depression.

Abstract

Keywords

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