An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Heather J. Cordell; James J. Fryett; Kazuko Ueno; Rebecca Darlay; Yoshihiro Aiba; Yuki Hitomi; Minae Kawashima; Nao Nishida; Seik Soon Khor; Olivier Gervais; Yosuke Kawai; Masao Nagasaki; Katsushi Tokunaga; Ruqi Tang; Yongyong Shi; Zhiqiang Li; Brian D. Juran; Elizabeth J. Atkinson; Alessio Gerussi; Marco Carbone; Rosanna Asselta; Angela Cheung; Andrade M de; Aris Baras; Julie Horowitz; Manuel A.R. Ferreira; Dylan Sun; David E. Jones; Steven Flack; Ann Spicer; Victoria L. Mulcahy; Jinyoung Byan; Younghun Han; Richard N. Sandford; Konstantinos N. Lazaridis; Christopher I. Amos; Gideon M. Hirschfield; Michael F. Seldin; Pietro Invernizzi; Katherine A. Siminovitch; Xiong Ma; Minoru Nakamura; George F. Mells; Katherine A. Siminovitch; Gideon M. Hirschfield; Andrew Mason; Catherine Vincent; Gang Xie; Jinyi Zhang; Ruqi Tang; Xiong Ma; Zhiqiang Li; Yongyong Shi; Andrea Affronti; Piero L. Almasio; D Alvaro; P Andreone; A Andriulli; F Azzaroli; PM Battezzati; A Benedetti; M Bragazzi; M Brunetto; S Bruno; V Calvaruso; V Cardinale; G Casella; N Cazzagon; A Ciaccio; B Coco; A Colli; G Colloredo; M Colombo; S Colombo; L Cristoferi; C Cursaro; LS Crocè; A Crosignani; D D’Amato; F Donato; G Elia; L Fabris; S Fagiuoli; C Ferrari; A Floreani; A Galli; E Giannini; I Grattagliano; P Lampertico; A Lleo; F Malinverno; Mancuso; Matthew Cramp

doi:10.1016/j.jhep.2021.04.055

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Heather J. Cordell
, James J. Fryett
, Kazuko Ueno
, Rebecca Darlay
, Yoshihiro Aiba
, Yuki Hitomi
, Minae Kawashima
, Nao Nishida
, Seik Soon Khor
, Olivier Gervais
, Yosuke Kawai
, Masao Nagasaki
, Katsushi Tokunaga
, Ruqi Tang
, Yongyong Shi
, Zhiqiang Li
, Brian D. Juran
, Elizabeth J. Atkinson
, Alessio Gerussi
, Marco Carbone

Rosanna Asselta, Angela Cheung, Andrade M de, Aris Baras, Julie Horowitz, Manuel A.R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Jinyoung Byan, Younghun Han, Richard N. Sandford, Konstantinos N. Lazaridis, Christopher I. Amos, Gideon M. Hirschfield, Michael F. Seldin, Pietro Invernizzi, Katherine A. Siminovitch, Xiong Ma, Minoru Nakamura, George F. Mells^*, Katherine A. Siminovitch, Gideon M. Hirschfield, Andrew Mason, Catherine Vincent, Gang Xie, Jinyi Zhang, Ruqi Tang, Xiong Ma, Zhiqiang Li, Yongyong Shi, Andrea Affronti, Piero L. Almasio, D Alvaro, P Andreone, A Andriulli, F Azzaroli, PM Battezzati, A Benedetti, M Bragazzi, M Brunetto, S Bruno, V Calvaruso, V Cardinale, G Casella, N Cazzagon, A Ciaccio, B Coco, A Colli, G Colloredo, M Colombo, S Colombo, L Cristoferi, C Cursaro, LS Crocè, A Crosignani, D D’Amato, F Donato, G Elia, L Fabris, S Fagiuoli, C Ferrari, A Floreani, A Galli, E Giannini, I Grattagliano, P Lampertico, A Lleo, F Malinverno, Mancuso, Matthew Cramp

^*Corresponding author for this work

Peninsula Medical School

Newcastle University
National Center for Global Health and Medicine
National Hospital Organization Nagasaki Medical Center
The University of Tokyo
Kyoto University
Shanghai Jiao Tong University
Mayo Clinic Rochester, MN
Azienda Ospedaliera San Gerardo Monza
University of Milan - Bicocca
Humanitas University
IRCCS Istituto Clinico Humanitas - Rozzano (Milano)
Regeneron
Regeneron Genetics Center
University of Cambridge
Baylor College of Medicine
University of Toronto
University of California at Davis
Toronto General Research Institute - University Health Network
University of Toronto/Lunenfeld-Tanenbaum Research Institute
Nagasaki Graduate School of Biomedical Sciences
University of Alberta
University of Montreal
Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello
University of Palermo

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Original language	English
Pages (from-to)	572-581
Number of pages	0
Journal	Journal of Hepatology
Volume	75
Issue number	3
Early online date	16 Aug 2021
DOIs	https://doi.org/10.1016/j.jhep.2021.04.055
Publication status	Published - Sept 2021

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Cordell, H. J., Fryett, J. J., Ueno, K., Darlay, R., Aiba, Y., Hitomi, Y., Kawashima, M., Nishida, N., Khor, S. S., Gervais, O., Kawai, Y., Nagasaki, M., Tokunaga, K., Tang, R., Shi, Y., Li, Z., Juran, B. D., Atkinson, E. J., Gerussi, A., ... Cramp, M. (2021). An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs. Journal of Hepatology, 75(3), 572-581. https://doi.org/10.1016/j.jhep.2021.04.055

@article{696fbe77d8964f1ba252ab4bf8c4ce0a,

title = "An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs",

author = "Cordell, \{Heather J.\} and Fryett, \{James J.\} and Kazuko Ueno and Rebecca Darlay and Yoshihiro Aiba and Yuki Hitomi and Minae Kawashima and Nao Nishida and Khor, \{Seik Soon\} and Olivier Gervais and Yosuke Kawai and Masao Nagasaki and Katsushi Tokunaga and Ruqi Tang and Yongyong Shi and Zhiqiang Li and Juran, \{Brian D.\} and Atkinson, \{Elizabeth J.\} and Alessio Gerussi and Marco Carbone and Rosanna Asselta and Angela Cheung and de, \{Andrade M\} and Aris Baras and Julie Horowitz and Ferreira, \{Manuel A.R.\} and Dylan Sun and Jones, \{David E.\} and Steven Flack and Ann Spicer and Mulcahy, \{Victoria L.\} and Jinyoung Byan and Younghun Han and Sandford, \{Richard N.\} and Lazaridis, \{Konstantinos N.\} and Amos, \{Christopher I.\} and Hirschfield, \{Gideon M.\} and Seldin, \{Michael F.\} and Pietro Invernizzi and Siminovitch, \{Katherine A.\} and Xiong Ma and Minoru Nakamura and Mells, \{George F.\} and Siminovitch, \{Katherine A.\} and Hirschfield, \{Gideon M.\} and Andrew Mason and Catherine Vincent and Gang Xie and Jinyi Zhang and Ruqi Tang and Xiong Ma and Zhiqiang Li and Yongyong Shi and Andrea Affronti and Almasio, \{Piero L.\} and D Alvaro and P Andreone and A Andriulli and F Azzaroli and PM Battezzati and A Benedetti and M Bragazzi and M Brunetto and S Bruno and V Calvaruso and V Cardinale and G Casella and N Cazzagon and A Ciaccio and B Coco and A Colli and G Colloredo and M Colombo and S Colombo and L Cristoferi and C Cursaro and LS Croc{\`e} and A Crosignani and D D{\textquoteright}Amato and F Donato and G Elia and L Fabris and S Fagiuoli and C Ferrari and A Floreani and A Galli and E Giannini and I Grattagliano and P Lampertico and A Lleo and F Malinverno and Mancuso and Matthew Cramp",

year = "2021",

month = sep,

doi = "10.1016/j.jhep.2021.04.055",

language = "English",

volume = "75",

pages = "572--581",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier B.V.",

number = "3",

}

Cordell, HJ, Fryett, JJ, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, SS, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, BD, Atkinson, EJ, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de, AM, Baras, A, Horowitz, J, Ferreira, MAR, Sun, D, Jones, DE, Flack, S, Spicer, A, Mulcahy, VL, Byan, J, Han, Y, Sandford, RN, Lazaridis, KN, Amos, CI, Hirschfield, GM, Seldin, MF, Invernizzi, P, Siminovitch, KA, Ma, X, Nakamura, M, Mells, GF, Siminovitch, KA, Hirschfield, GM, Mason, A, Vincent, C, Xie, G, Zhang, J, Tang, R, Ma, X, Li, Z, Shi, Y, Affronti, A, Almasio, PL, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, PM, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Crocè, LS, Crosignani, A, D’Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, & Cramp, M 2021, 'An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs', Journal of Hepatology, vol. 75, no. 3, pp. 572-581. https://doi.org/10.1016/j.jhep.2021.04.055

TY - JOUR

T1 - An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

AU - Cordell, Heather J.

AU - Fryett, James J.

AU - Ueno, Kazuko

AU - Darlay, Rebecca

AU - Aiba, Yoshihiro

AU - Hitomi, Yuki

AU - Kawashima, Minae

AU - Nishida, Nao

AU - Khor, Seik Soon

AU - Gervais, Olivier

AU - Kawai, Yosuke

AU - Nagasaki, Masao

AU - Tokunaga, Katsushi

AU - Tang, Ruqi

AU - Shi, Yongyong

AU - Li, Zhiqiang

AU - Juran, Brian D.

AU - Atkinson, Elizabeth J.

AU - Gerussi, Alessio

AU - Carbone, Marco

AU - Asselta, Rosanna

AU - Cheung, Angela

AU - de, Andrade M

AU - Baras, Aris

AU - Horowitz, Julie

AU - Ferreira, Manuel A.R.

AU - Sun, Dylan

AU - Jones, David E.

AU - Flack, Steven

AU - Spicer, Ann

AU - Mulcahy, Victoria L.

AU - Byan, Jinyoung

AU - Han, Younghun

AU - Sandford, Richard N.

AU - Lazaridis, Konstantinos N.

AU - Amos, Christopher I.

AU - Hirschfield, Gideon M.

AU - Seldin, Michael F.

AU - Invernizzi, Pietro

AU - Siminovitch, Katherine A.

AU - Ma, Xiong

AU - Nakamura, Minoru

AU - Mells, George F.

AU - Siminovitch, Katherine A.

AU - Hirschfield, Gideon M.

AU - Mason, Andrew

AU - Vincent, Catherine

AU - Xie, Gang

AU - Zhang, Jinyi

AU - Tang, Ruqi

AU - Ma, Xiong

AU - Li, Zhiqiang

AU - Shi, Yongyong

AU - Affronti, Andrea

AU - Almasio, Piero L.

AU - Alvaro, D

AU - Andreone, P

AU - Andriulli, A

AU - Azzaroli, F

AU - Battezzati, PM

AU - Benedetti, A

AU - Bragazzi, M

AU - Brunetto, M

AU - Bruno, S

AU - Calvaruso, V

AU - Cardinale, V

AU - Casella, G

AU - Cazzagon, N

AU - Ciaccio, A

AU - Coco, B

AU - Colli, A

AU - Colloredo, G

AU - Colombo, M

AU - Colombo, S

AU - Cristoferi, L

AU - Cursaro, C

AU - Crocè, LS

AU - Crosignani, A

AU - D’Amato, D

AU - Donato, F

AU - Elia, G

AU - Fabris, L

AU - Fagiuoli, S

AU - Ferrari, C

AU - Floreani, A

AU - Galli, A

AU - Giannini, E

AU - Grattagliano, I

AU - Lampertico, P

AU - Lleo, A

AU - Malinverno, F

AU - Mancuso, null

AU - Cramp, Matthew

PY - 2021/9

Y1 - 2021/9

UR - https://pearl.plymouth.ac.uk/pms-research/1714/

U2 - 10.1016/j.jhep.2021.04.055

DO - 10.1016/j.jhep.2021.04.055

M3 - Article

SN - 0168-8278

VL - 75

SP - 572

EP - 581

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 3

ER -

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

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