An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors.

MR Zamani; JR Dupere; DR Bristow

doi:10.1016/0304-3940(94)90314-x

An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors.

MR Zamani, JR Dupere, DR Bristow

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Histamine, acting via H1 receptors, dose-dependently stimulated [3H]inositol phosphate production in GT1-7 neuronal cells. GT1-7 cells also responded to Substance P but not to other neuroactive drugs tested. Acute histamine pretreatment desensitised the histamine-induced response, resulting in a reduction in the maximal response and a slower time-course of [3H]-inositol phosphate production. The desensitisation phenomenon was reversible, with full recovery by 2 h.

Original language	English
Pages (from-to)	159-162
Number of pages	0
Journal	Neurosci Lett
Volume	178
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)90314-x
Publication status	Published - 29 Aug 1994

Keywords

Animals
Carbachol
Cell Line
Transformed
Dose-Response Relationship
Drug
Glutamic Acid
Histamine
Histamine Antagonists
Histamine H1 Antagonists
Hypothalamus
Inositol Phosphates
Kinetics
Mice
Neurons
Neuropeptide Y
Piperidines
Pyrimidinones
Ranitidine
Receptors
Histamine H1
Serotonin
Substance P
Tritium

Access to Document

10.1016/0304-3940(94)90314-x

Cite this

@article{47c59ac165ae47e6950f3bd0ba7cbeb1,

title = "An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors.",

abstract = "Histamine, acting via H1 receptors, dose-dependently stimulated [3H]inositol phosphate production in GT1-7 neuronal cells. GT1-7 cells also responded to Substance P but not to other neuroactive drugs tested. Acute histamine pretreatment desensitised the histamine-induced response, resulting in a reduction in the maximal response and a slower time-course of [3H]-inositol phosphate production. The desensitisation phenomenon was reversible, with full recovery by 2 h.",

keywords = "Animals, Carbachol, Cell Line, Transformed, Dose-Response Relationship, Drug, Glutamic Acid, Histamine, Histamine Antagonists, Histamine H1 Antagonists, Hypothalamus, Inositol Phosphates, Kinetics, Mice, Neurons, Neuropeptide Y, Piperidines, Pyrimidinones, Ranitidine, Receptors, Histamine H1, Serotonin, Substance P, Tritium",

author = "MR Zamani and JR Dupere and DR Bristow",

year = "1994",

month = aug,

day = "29",

doi = "10.1016/0304-3940(94)90314-x",

language = "English",

volume = "178",

pages = "159--162",

journal = "Neurosci Lett",

issn = "0304-3940",

number = "1",

}

TY - JOUR

T1 - An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors.

AU - Zamani, MR

AU - Dupere, JR

AU - Bristow, DR

PY - 1994/8/29

Y1 - 1994/8/29

N2 - Histamine, acting via H1 receptors, dose-dependently stimulated [3H]inositol phosphate production in GT1-7 neuronal cells. GT1-7 cells also responded to Substance P but not to other neuroactive drugs tested. Acute histamine pretreatment desensitised the histamine-induced response, resulting in a reduction in the maximal response and a slower time-course of [3H]-inositol phosphate production. The desensitisation phenomenon was reversible, with full recovery by 2 h.

AB - Histamine, acting via H1 receptors, dose-dependently stimulated [3H]inositol phosphate production in GT1-7 neuronal cells. GT1-7 cells also responded to Substance P but not to other neuroactive drugs tested. Acute histamine pretreatment desensitised the histamine-induced response, resulting in a reduction in the maximal response and a slower time-course of [3H]-inositol phosphate production. The desensitisation phenomenon was reversible, with full recovery by 2 h.

KW - Animals

KW - Carbachol

KW - Cell Line

KW - Transformed

KW - Dose-Response Relationship

KW - Drug

KW - Glutamic Acid

KW - Histamine

KW - Histamine Antagonists

KW - Histamine H1 Antagonists

KW - Hypothalamus

KW - Inositol Phosphates

KW - Kinetics

KW - Mice

KW - Neurons

KW - Neuropeptide Y

KW - Piperidines

KW - Pyrimidinones

KW - Ranitidine

KW - Receptors

KW - Histamine H1

KW - Serotonin

KW - Substance P

KW - Tritium

U2 - 10.1016/0304-3940(94)90314-x

DO - 10.1016/0304-3940(94)90314-x

M3 - Article

SN - 0304-3940

VL - 178

SP - 159

EP - 162

JO - Neurosci Lett

JF - Neurosci Lett

IS - 1

ER -

An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors.

Abstract

Keywords

Access to Document

Fingerprint

Cite this