Adult brain tumour research in 2024: Status, challenges and recommendations

Karin Purshouse; Helen J. Bulbeck; Alasdair G. Rooney; Karen E. Noble; Ross D. Carruthers; Gerard Thompson; Petra Hamerlik; Christina Yap; Kathreena M. Kurian; Sarah J. Jefferies; Juanita S. Lopez; Michael D. Jenkinson; C. Oliver Hanemann; Lucy F. Stead

doi:10.1111/nan.12979

Adult brain tumour research in 2024: Status, challenges and recommendations

Karin Purshouse, Helen J. Bulbeck, Alasdair G. Rooney, Karen E. Noble, Ross D. Carruthers, Gerard Thompson, Petra Hamerlik, Christina Yap, Kathreena M. Kurian, Sarah J. Jefferies, Juanita S. Lopez, Michael D. Jenkinson, C. Oliver Hanemann, Lucy F. Stead^*

^*Corresponding author for this work

Peninsula Medical School

Research output: Contribution to journal › Review article › peer-review

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Abstract

In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government pledging £20m of funding, to be paralleled with £25m from Cancer Research UK, specifically for neuro-oncology research over the subsequent 5 years. Herein, we review if and how the adult brain tumour research landscape in the United Kingdom has changed over that time and what challenges and bottlenecks remain. We have identified seven universal brain tumour research priorities and three cross-cutting themes, which span the research spectrum from bench to bedside and back again. We discuss the status, challenges and recommendations for each one, specific to the United Kingdom.

Original language	English
Article number	e12979
Journal	Neuropathology and Applied Neurobiology
Volume	50
Issue number	2
DOIs	https://doi.org/10.1111/nan.12979
Publication status	Published - 11 Apr 2024

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Neurology
Neurology (clinical)
Physiology (medical)

Keywords

brain cancer

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NAN-2024-0026-RESUBMISSIONDv2_CLEANAccepted author manuscript, 753 KB

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Purshouse, K., Bulbeck, H. J., Rooney, A. G., Noble, K. E., Carruthers, R. D., Thompson, G., Hamerlik, P., Yap, C., Kurian, K. M., Jefferies, S. J., Lopez, J. S., Jenkinson, M. D., Hanemann, C. O., & Stead, L. F. (2024). Adult brain tumour research in 2024: Status, challenges and recommendations. Neuropathology and Applied Neurobiology, 50(2), Article e12979. https://doi.org/10.1111/nan.12979

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title = "Adult brain tumour research in 2024: Status, challenges and recommendations",

abstract = "In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government pledging £20m of funding, to be paralleled with £25m from Cancer Research UK, specifically for neuro-oncology research over the subsequent 5 years. Herein, we review if and how the adult brain tumour research landscape in the United Kingdom has changed over that time and what challenges and bottlenecks remain. We have identified seven universal brain tumour research priorities and three cross-cutting themes, which span the research spectrum from bench to bedside and back again. We discuss the status, challenges and recommendations for each one, specific to the United Kingdom.",

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AU - Purshouse, Karin

AU - Bulbeck, Helen J.

AU - Rooney, Alasdair G.

AU - Noble, Karen E.

AU - Carruthers, Ross D.

AU - Thompson, Gerard

AU - Hamerlik, Petra

AU - Yap, Christina

AU - Kurian, Kathreena M.

AU - Jefferies, Sarah J.

AU - Lopez, Juanita S.

AU - Jenkinson, Michael D.

AU - Hanemann, C. Oliver

AU - Stead, Lucy F.

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AB - In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK Minister for Life Sciences to form a brain tumour research task and finish group. This resulted, in 2018, with the UK government pledging £20m of funding, to be paralleled with £25m from Cancer Research UK, specifically for neuro-oncology research over the subsequent 5 years. Herein, we review if and how the adult brain tumour research landscape in the United Kingdom has changed over that time and what challenges and bottlenecks remain. We have identified seven universal brain tumour research priorities and three cross-cutting themes, which span the research spectrum from bench to bedside and back again. We discuss the status, challenges and recommendations for each one, specific to the United Kingdom.

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Adult brain tumour research in 2024: Status, challenges and recommendations

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ASJC Scopus subject areas

Keywords

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