A concise entry into nonsymmetrical alkyl polyamines.

T Pirali; G Callipari; E Ercolano; AA Genazzani; GB Giovenzana; GC Tron

doi:10.1021/ol801612r

A concise entry into nonsymmetrical alkyl polyamines.

T Pirali, G Callipari, E Ercolano, AA Genazzani, GB Giovenzana, GC Tron

Peninsula Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of nonsymmetrical polyamines (PAs) has, up to now, been problematic due to lengthy synthetic procedures, lack of regioselectivity, and very poor atom economy. An innovative synthetic protocol for nonsymmetrical PAs using a modified Ugi reaction ( N-split Ugi) which simplifies the synthesis of these tricky compounds is described. We believe that this new synthesis may open the door for the generation of new and pharmacologically active PAs.

Original language	English
Pages (from-to)	4199-4202
Number of pages	0
Journal	Org Lett
Volume	10
Issue number	19
DOIs	https://doi.org/10.1021/ol801612r
Publication status	Published - 2 Oct 2008

Keywords

Antineoplastic Agents
Biological Products
Cell Line
Tumor
Humans
Inhibitory Concentration 50
Polyamines

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10.1021/ol801612r

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AU - Callipari, G

AU - Ercolano, E

AU - Genazzani, AA

AU - Giovenzana, GB

AU - Tron, GC

PY - 2008/10/2

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KW - Antineoplastic Agents

KW - Biological Products

KW - Cell Line

KW - Tumor

KW - Humans

KW - Inhibitory Concentration 50

KW - Polyamines

U2 - 10.1021/ol801612r

DO - 10.1021/ol801612r

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JO - Org Lett

JF - Org Lett

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A concise entry into nonsymmetrical alkyl polyamines.

Abstract

Keywords

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