A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

Alexander Walkden; Mohammed Salem; Marios Stavrakas; Hisham Khalil

doi:10.1177/01455613211037086

A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

Alexander Walkden, Mohammed Salem, Marios Stavrakas, Hisham Khalil

University Hospitals Plymouth NHS Trust

Research output: Contribution to journal › Article › peer-review

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Abstract

SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.

Original language	English
Pages (from-to)	140-142
Number of pages	3
Journal	Ear, Nose and Throat Journal
Volume	103
Issue number	3
Early online date	14 Sept 2021
DOIs	https://doi.org/10.1177/01455613211037086 https://doi.org/10.1177/01455613211037086
Publication status	Published - 14 Sept 2021
Externally published	Yes

Keywords

Humans
Granulomatosis with Polyangiitis/complications
Antibodies, Antineutrophil Cytoplasmic
Inflammation
Respiratory System

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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01455613211037086Final published version, 250 KB

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title = "A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis",

abstract = "SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.",

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author = "Alexander Walkden and Mohammed Salem and Marios Stavrakas and Hisham Khalil",

year = "2021",

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day = "14",

doi = "10.1177/01455613211037086",

language = "English",

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pages = "140--142",

journal = "Ear, Nose and Throat Journal",

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TY - JOUR

T1 - A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

AU - Walkden, Alexander

AU - Salem, Mohammed

AU - Stavrakas, Marios

AU - Khalil, Hisham

PY - 2021/9/14

Y1 - 2021/9/14

N2 - SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.

AB - SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.

KW - Humans

KW - Granulomatosis with Polyangiitis/complications

KW - Antibodies, Antineutrophil Cytoplasmic

KW - Inflammation

KW - Respiratory System

UR - https://pearl.plymouth.ac.uk/pms-research/541

U2 - 10.1177/01455613211037086

DO - 10.1177/01455613211037086

M3 - Article

C2 - 34519237

SN - 0014-5491

VL - 103

SP - 140

EP - 142

JO - Ear, Nose and Throat Journal

JF - Ear, Nose and Throat Journal

IS - 3

ER -

A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

Abstract

Keywords

UN SDGs

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