A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

Alexander Walkden; Mohammed Salem; Marios Stavrakas; Hisham Khalil

doi:10.1177/01455613211037086

A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

Alexander Walkden
, Mohammed Salem
, Marios Stavrakas
, Hisham Khalil

University Hospitals Plymouth NHS Trust

Research output: Contribution to journal › Article › peer-review

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Abstract

SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.

Original language	English
Pages (from-to)	140-142
Number of pages	3
Journal	Eye, ear, nose & throat monthly
Volume	103
Issue number	3
Early online date	14 Sept 2021
DOIs	https://doi.org/10.1177/01455613211037086 https://doi.org/10.1177/01455613211037086
Publication status	Published - 14 Sept 2021
Externally published	Yes

Keywords

Humans
Granulomatosis with Polyangiitis/complications
Antibodies, Antineutrophil Cytoplasmic
Inflammation
Respiratory System

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title = "A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis",

abstract = "SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.",

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doi = "10.1177/01455613211037086",

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T1 - A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

AU - Walkden, Alexander

AU - Salem, Mohammed

AU - Stavrakas, Marios

AU - Khalil, Hisham

PY - 2021/9/14

Y1 - 2021/9/14

N2 - SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.

AB - SIGNIFICANCE STATEMENT: Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.

KW - Humans

KW - Granulomatosis with Polyangiitis/complications

KW - Antibodies, Antineutrophil Cytoplasmic

KW - Inflammation

KW - Respiratory System

UR - https://pearl.plymouth.ac.uk/pms-research/541

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DO - 10.1177/01455613211037086

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JO - Eye, ear, nose & throat monthly

JF - Eye, ear, nose & throat monthly

IS - 3

ER -

A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis

Abstract

Keywords

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