Overview
Profile summary
April 2014 – July 2022 Co-founder and Director at Spectromics Ltd (http://www.spectromics.com/)
May 2013 – Reader in Medical Microbiology, University of Plymouth
June 2011 – Senior Lecturer in Medical Microbiology, University of Manchester
June 2001 – Lecturer in Medical Microbiology, University of Manchester
Following BSc and PhD studies in Newcastle, I completed a number of postdoc projects in Aberdeen, Antarctica, Bristol, Liverpool and New Zealand, before taking up a lectureship in Manchester.
Lead for Antibiotic Resistant Pathogens Research Group
Current lab members:
- Dr Grant January (PDRA) – Newton Fund/MRC/SAMRC – South Africa-UK Antibiotic Accelerator
- Dr Katie Muddiman - Senior Technician in AMR
- Jack Kay (Royal Commission of 1851 Industrial PhD candidate)
- Neil Powell (NIHR Fellowship PhD candidate)
- Sean Kelly (PhD candidate)
- Jazmin Conway (One Ocean Hub, GCRF PhD candidate – co-supervisor with Professor Kerry Howell)
- Kudzai Hwengwere (ARIES PhD candidate - co-supervisor with Professor Kerry Howell and Prof Mel Clark, BAS)
- Braith Grey (PhD candidate - co-supervisor with Dr Tina Joshi)
- Matthew McKracken (PhD candidate - co-supervision with Dr Tina Joshi)
- Darshana Srivastava (PhD candidate - co-supervision with Dr Phil Warburton)
Professional memberships
Member of the American Society for Microbiology
Member of the European Society for Clinical Microbiology
Member of the British Society for Antimicrobial Chemotherapy
Roles on external bodies
Guest Associate Editor
Frontiers in Microbiology, 2022 – Bacteriocins and other Ribosomally Synthesised and Post-translationally modified Peptides (RiPPs) as modulators of the microbiome
Supervised research degrees
I have supervised nearly 30 PhD students and over 70 MSc research projects. These projects have all been in the field of medical microbiology and have involved collaborators at UK universities, UKHSA (formerly Public Health England & HPA) and NHS Trusts.
Current PhD students (Director of studies)
Neil Powell (2020-2024) - Penicillin allergy patient classification
Jack Kay (2020-2023) - Discovery and design of of novel antimicrobial peptides
Sean Kelly (2021-2025) - Emerging human respiratory pathogens
Sophie Tauber (2023-2027) - Developing a novel vaccine for Group B Streptococcus
Current PhD students (Co-supervisor)
Jazmin Conway (2021-2024) - Marine biodiscovery for AMR
Kudzai Hwengwere (2021-2025) - Antarctic marine microbial ecology and natural product discovery
Braith Grey (2021-2024) - Toward a low-cost, rapid point-of-care biosensor for detection of Antibiotic Resistant Urinary Tract Infections
Matthew McKracken (2022-2025) - Biocide resistance in human pathogens
Darshana Srivastava (2023-2027) - Novel antimicrobials from flowering plants
Current ResM students (co-supervisor)
Alistair White (2022-2024) - Novel molecular diagnostics for AMR
Recent PhD Graduates (Director of studies)
Matthew Koch (2017-2021) - SfAM PhD Studentship Discovery of novel antimicrobials from deep sea sponges
Abdu Aldarhami (2015-2019) - Novel antimicrobials for therapy of Gram positive infections
Nizar Saeedi (2014-2018) - Pathogenenesis of ST127 uropathogenic E coli
Rob O'Hara (2015-2018) - Epidemiology of ST127 uropathogenic E coli
Recent PhD Graduates (co-supervisor)
James Butler (2018-2022) - Novel antimicrobial surfaces to reduce healthcare associated infections
Poppy Best (2017-2021) - Bioactivity and ecology of bacteria from deep sea sponges
Sam Gould (2015-2018) - 3D models to study oral infections
Connor Wood (2015-2018) - Superinfection of influenza virus
Barbara Durante (2015-2018) - Immunological effects of antimicrobial peptides
Teaching interests
MSc Biomedical Sciences
Contributing to modules BIOM5003 (Contemporary Aspects of Infection and Immunity), BIOM5005 (Project Design and Development), BIOM5006 (Research Project), BIOM5008 (Clinical Microbiology), BIOM5010 (Personalised Medicine).
BSc Biomedical Sciences.
Contributing to Modules BIOM3001, BIOM3003, BIOM3015, BIOM3016.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 14 Life Below Water
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Collaborations and top research areas from the last five years
Research output
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What’s really down the hospital plughole?
Butler, J. & Upton, M., Aug 2023, In: Journal of Hospital Infection. 0, 0Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
Physicochemical and metagenomic analysis of samples from the Roman Baths (Bath, UK) reveals high bacterial and archaeal diversity and a potential for antimicrobial discovery
Fina, E., Kiernan, M., Whatmough, B., Clark, N. J., Conway, J., Wieczorek, I. W., Carey, L., Matyjaszkiewicz, Z., Warburton, P. J., Upton, M. & Hutt, L. P., 1 Jun 2024, In: The Microbe. 3, 100075.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Downloads (Pure) -
Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential
Hesketh-Best, P. J., January, G. G., Koch, M. J., Warburton, P. J., Howell, K. L. & Upton, M., 22 Feb 2023, In: FEMS Microbes. 0, 0Research output: Contribution to journal › Article › peer-review
Open AccessFile95 Downloads (Pure) -
Hospital sink traps as a potential source of the emerging multidrug-resistant pathogen Cupriavidus pauculus: characterization and draft genome sequence of strain MF1
Butler, J., Kelly, S. D., Muddiman, K. J., Besinis, A. & Upton, M., 3 Feb 2022, In: Journal of Medical Microbiology. 71, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Downloads (Pure) -
Assessing a penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation reporting healthcare workers' experiences
Powell, N., Upton, M., Kent, B., Sandoe, J. A. T. & Tonkin-Crine, S., 1 Oct 2025, In: JAC-Antimicrobial Resistance. 7, 5, dlaf174.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure)