Professor Mathew Upton

    Accepting PhD Students

    PhD projects

    Subject areas include antimicrobial natural product discovery and vaccine design and development

    Overview

    Profile summary

    August 2018 – Professor of Medical Microbiology, University of PlymouthJune 2018 – Founder and Chief Scientific Officer at Amprologix Ltd (@amprologix)
    April 2014 – July 2022 Co-founder and Director at Spectromics Ltd (http://www.spectromics.com/)
    May 2013 – Reader in Medical Microbiology, University of Plymouth
    June 2011 – Senior Lecturer in Medical Microbiology, University of Manchester
    June 2001 – Lecturer in Medical Microbiology, University of Manchester
    Following BSc and PhD studies in Newcastle, I completed a number of postdoc projects in Aberdeen, Antarctica, Bristol, Liverpool and New Zealand, before taking up a lectureship in Manchester.
    Lead for Antibiotic Resistant Pathogens Research Group
    Current lab members:
    • Dr Grant January (PDRA) – Newton Fund/MRC/SAMRC – South Africa-UK Antibiotic Accelerator
    • Dr Katie Muddiman - Senior Technician in AMR
    • Jack Kay (Royal Commission of 1851 Industrial PhD candidate)
    • Neil Powell (NIHR Fellowship PhD candidate)
    • Sean Kelly (PhD candidate)
    • Jazmin Conway (One Ocean Hub, GCRF PhD candidate – co-supervisor with Professor Kerry Howell)
    • Kudzai Hwengwere (ARIES PhD candidate - co-supervisor with Professor Kerry Howell and Prof Mel Clark, BAS)
    • Braith Grey (PhD candidate - co-supervisor with Dr Tina Joshi)
    • Matthew McKracken (PhD candidate - co-supervision with Dr Tina Joshi)
    • Darshana Srivastava (PhD candidate - co-supervision with Dr Phil Warburton

    Professional memberships

    Fellow of the Royal Society of BiologyMember of the Microbiology Society
    Member of the American Society for Microbiology
    Member of the European Society for Clinical Microbiology
    Member of the British Society for Antimicrobial Chemotherapy

    Roles on external bodies

    WHO Technical Advisory Group on Vaccines for AMR - Observer, 2022-2023
    Guest Associate Editor
    Frontiers in Microbiology, 2022 – Bacteriocins and other Ribosomally Synthesised and Post-translationally modified Peptides (RiPPs) as modulators of the microbiome

    Supervised research degrees

    I have supervised nearly 30 PhD students and over 70 MSc research projects. These projects have all been in the field of medical microbiology and have involved collaborators at UK universities, UKHSA (formerly Public Health England & HPA) and NHS Trusts.

    Current PhD students (Director of studies)
    Neil Powell (2020-2024) - Penicillin allergy patient classification

    Jack Kay (2020-2023) - Discovery and design of of novel antimicrobial peptides

    Sean Kelly (2021-2025) - Emerging human respiratory pathogens

    Sophie Tauber (2023-2027) - Developing a novel vaccine for Group B Streptococcus


    Current PhD students (Co-supervisor)
    Jazmin Conway (2021-2024) - Marine biodiscovery for AMR

    Kudzai Hwengwere (2021-2025) - Antarctic marine microbial ecology and natural product discovery

    Braith Grey (2021-2024) - Toward a low-cost, rapid point-of-care biosensor for detection of Antibiotic Resistant Urinary Tract Infections

    Matthew McKracken (2022-2025) - Biocide resistance in human pathogens

    Darshana Srivastava (2023-2027) - Novel antimicrobials from flowering plants

    Current ResM students (co-supervisor)
    Alistair White (2022-2024) - Novel molecular diagnostics for AMR


    Recent PhD Graduates (Director of studies)
    Matthew Koch (2017-2021) - SfAM PhD Studentship Discovery of novel antimicrobials from deep sea sponges
    Abdu Aldarhami (2015-2019) - Novel antimicrobials for therapy of Gram positive infections
    Nizar Saeedi (2014-2018) - Pathogenenesis of ST127 uropathogenic E coli
    Rob O'Hara (2015-2018) - Epidemiology of ST127 uropathogenic E coli


    Recent PhD Graduates (co-supervisor)
    James Butler (2018-2022) - Novel antimicrobial surfaces to reduce healthcare associated infections
    Poppy Best (2017-2021) - Bioactivity and ecology of bacteria from deep sea sponges
    Sam Gould (2015-2018) - 3D models to study oral infections
    Connor Wood (2015-2018) - Superinfection of influenza virus
    Barbara Durante (2015-2018) - Immunological effects of antimicrobial peptides

    Teaching interests

    Areas of teaching interest relate to medical microbiology, bacterial genomics and antibiotic resistance.
    MSc Biomedical Sciences
    Contributing to modules BIOM5003 (Contemporary Aspects of Infection and Immunity), BIOM5005 (Project Design and Development), BIOM5006 (Research Project), BIOM5008 (Clinical Microbiology), BIOM5010 (Personalised Medicine).
    BSc Biomedical Sciences.
    Contributing to Modules BIOM3001, BIOM3003, BIOM3015, BIOM3016.

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being
    • SDG 7 - Affordable and Clean Energy
    • SDG 9 - Industry, Innovation, and Infrastructure
    • SDG 14 - Life Below Water

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