Research output per year
Research output per year
Research output
- 41 results
Search results
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2022
Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice
Van, D. P. M., Dimond, A., Galvão, A. M., Millership, S. J., To, W., Prodani, C., McNamara, G., Bruno, L., Sardini, A., Webster, Z., McGinty, J., French, P. M. W., Uren, A. G., Castillo-Fernandez, J., Watkinson, W., Ferguson-Smith, A. C., Merkenschlager, M., John, R. M., Kelsey, G. & Fisher, A. G., 5 May 2022, (E-pub ahead of print) In: Nature Communications. 13, 1Research output: Contribution to journal › Article › peer-review
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2021
Forward and Reverse Genetics of B Cell Malignancies: From Insertional Mutagenesis to CRISPR-Cas
Dawes, J. C. & Uren, A. G., 13 Aug 2021, In: Frontiers in Immunology. 12, 0Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
2020
Epigenetic change induced by in utero dietary challenge provokes phenotypic variability across multiple generations of mice
Van, D. P. M., Galvao, A., Millership, S., To, W., Dimond, A., Prodani, C., McNamara, G., Bruno, L., Sardini, A., Webster, Z., McGinty, J., French, P., Uren, A., Castillo-Fernandez, J., John, R., Ferguson-Smith, A., Merkenschlager, M., Kelsey, G. & Fisher, A., 7 Aug 2020.Research output: Working paper › Preprint
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Galactose‐modified duocarmycin prodrugs as senolytics
Guerrero, A., Guiho, R., Herranz, N., Uren, A., Withers, D. J., Martínez‐Barbera, J., Tietze, L. F. & Gil, J., Apr 2020, In: Aging Cell. 19, 4Research output: Contribution to journal › Article › peer-review
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LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites
Dawes, J. C., Webster, P., Iadarola, B., Garcia-Diaz, C., Dore, M., Bolt, B. J., Dewchand, H., Dharmalingam, G., McLatchie, A. P., Kaczor, J., Caceres, J. J., Paccanaro, A., Game, L., Parrinello, S. & Uren, A. G., Dec 2020, In: Mobile DNA. 11, 1Research output: Contribution to journal › Article › peer-review
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2019
Author Correction: Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
Webster, P., Dawes, J. C., Dewchand, H., Takacs, K., Iadarola, B., Bolt, B. J., Caceres, J. J., Kaczor, J., Dharmalingam, G., Dore, M., Game, L., Adejumo, T., Elliott, J., Naresh, K., Karimi, M., Rekopoulou, K., Tan, G., Paccanaro, A. & Uren, A. G., 6 Mar 2019, (E-pub ahead of print) In: Nature Communications. 10, 1Research output: Contribution to journal › Article › peer-review
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Cardiac glycosides are broad-spectrum senolytics
Guerrero, A., Herranz, N., Sun, B., Wagner, V., Gallage, S., Guiho, R., Wolter, K., Pombo, J., Irvine, E. E., Innes, A. J., Birch, J., Glegola, J., Manshaei, S., Heide, D., Dharmalingam, G., Harbig, J., Olona, A., Behmoaras, J., Dauch, D. & Uren, A. G. & 6 others, , 21 Oct 2019, (E-pub ahead of print) In: Nature Metabolism. 1, 11, p. 1074-1088Research output: Contribution to journal › Article › peer-review
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Galactose-modified duocarmycin prodrugs as senolytics
Guerrero, A., Guiho, R., Herranz, N., Uren, A., Withers, D., Martínez-Barbera, J., Tietze, L. & Gil, J., 24 Aug 2019.Research output: Working paper › Preprint
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2018
Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates
Webster, P., Dawes, J. C., Dewchand, H., Takacs, K., Iadarola, B., Bolt, B. J., Caceres, J. J., Kaczor, J., Dharmalingam, G., Dore, M., Game, L., Adejumo, T., Elliott, J., Naresh, K., Karimi, M., Rekopoulou, K., Tan, G., Paccanaro, A. & Uren, A. G., 9 Jul 2018, (E-pub ahead of print) In: Nature Communications. 9, 1Research output: Contribution to journal › Article › peer-review
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2017
Tracking Subclonal Mutation Frequencies Throughout Lymphomagenesis Identifies Cancer Drivers in Mouse Models of Lymphoma
Webster, P., Dawes, J., Dewchand, H., Takacs, K., Iadarola, B., Bolt, B., Caceres, J., Kaczor, J., Game, L., Adejumo, T., Elliott, J., Naresh, K., Tan, G., Dharmalingam, G., Paccanaro, A. & Uren, A., 29 Jun 2017.Research output: Working paper › Preprint
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Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults
Van, D. P. M., Abbas, A., Feytout, A., McNamara, G., Bruno, L., To, W. K., Dimond, A., Sardini, A., Webster, Z., McGinty, J., Paul, E. J., Ungless, M. A., French, P. M. W., Withers, D. J., Uren, A., Ferguson-Smith, A. C., Merkenschlager, M., John, R. M. & Fisher, A. G., Jan 2017, In: Cell Reports. 18, 5, p. 1090-1099Research output: Contribution to journal › Article › peer-review
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2015
Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
Curry, E., Green, I., Chapman-Rothe, N., Shamsaei, E., Kandil, S., Cherblanc, F. L., Payne, L., Bell, E., Ganesh, T., Srimongkolpithak, N., Caron, J., Li, F., Uren, A. G., Snyder, J. P., Vedadi, M., Fuchter, M. J. & Brown, R., Dec 2015, In: Clinical Epigenetics. 7, 1Research output: Contribution to journal › Article › peer-review
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2013
Mutational Genomics for Cancer Pathway Discovery
de, R. J., Kool, J., Uren, A. G., Bot, J., de, J. J., Rust, A. G., Berns, A., van, L. M., Adams, D. J., Wessels, L. & Reinders, M., 2013, Pattern Recognition in Bioinformatics. Vol. 0. p. 35-46Research output: Chapter in Book/Report/Conference proceeding › Conference proceedings published in a book › peer-review
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2012
GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors
Westerman, B. A., Blom, M., Tanger, E., van, D. V. M., Song, J. Y., van, S. M., Gadiot, J., Cornelissen-Steijger, P., Zevenhoven, J., Prosser, H. M., Uren, A., Aronica, E. & van, L. M., 4 May 2012, (E-pub ahead of print) In: PLoS ONE. 7, 5, p. e35943-e35943Research output: Contribution to journal › Article › peer-review
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2011
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
March, H. N., Rust, A. G., Wright, N. A., ten, H. J., de, R. J., Eldridge, M., van, D. W. L., Berns, A., Gadiot, J., Uren, A., Kemp, R., Arends, M. J., Wessels, L. F. A., Winton, D. J. & Adams, D. J., Dec 2011, In: Nature Genetics. 43, 12, p. 1202-1209Research output: Contribution to journal › Article › peer-review
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Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
Vassiliou, G. S., Cooper, J. L., Rad, R., Li, J., Rice, S., Uren, A., Rad, L., Ellis, P., Andrews, R., Banerjee, R., Grove, C., Wang, W., Liu, P., Wright, P., Arends, M. & Bradley, A., May 2011, In: Nature Genetics. 43, 5, p. 470-475Research output: Contribution to journal › Article › peer-review
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2010
A CONDITIONAL KNOCK-IN ALLELE OF THE TYPE A CYTOPLASMIC NUCLEOPHOSMIN MUTATION COOPERATES WITH A NOVEL SLEEPING BEAUTY TRANSPOSON TO CAUSE ACUTE MYELOID LEUKAEMIA IN MICE
Vassiliou, G., Cooper, J., Rad, R., Rice, S., Arends, M., Wright, P., Rad, L., Banerjee, R., Yusa, K., Ellis, P., Grove, C., Uren, A., Huntly, B., Adams, D., Li, J. & Bradley, A., 2010, In: HAEMATOLOGICA-THE HEMATOLOGY JOURNAL. 95, 0, p. 240-241Research output: Contribution to journal › Conference proceedings published in a journal › peer-review
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Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Kool, J., Uren, A. G., Martins, C. P., Sie, D., de, R. J., Turner, G., van, U. M., Matentzoglu, K., Lagcher, W., Krimpenfort, P., Gadiot, J., Pritchard, C., Lenz, J., Lund, A. H., Jonkers, J., Rogers, J., Adams, D. J., Wessels, L., Berns, A. & van, L. M., 15 Jan 2010, In: Cancer Research. 70, 2, p. 520-531Research output: Contribution to journal › Article › peer-review
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Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach
Mattison, J., Kool, J., Uren, A. G., de, R. J., Wessels, L., Jonkers, J., Bignell, G. R., Butler, A., Rust, A. G., Brosch, M., Wilson, C. H., van, D. W. L., Largaespada, D. A., Stratton, M. R., Futreal, P. A., van, L. M., Berns, A., Collier, L. S., Hubbard, T. & Adams, D. J., 1 Feb 2010, In: Cancer Research. 70, 3, p. 883-895Research output: Contribution to journal › Article › peer-review
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2009
336 Identification of cancer genes and their collaborative networks by large-scale mutagenesis in tumour prone mice
Berns, A., Uren, A., Kool, J., De, R. J., Mattison, J., Jonkers, J., Wessels, L., Adams, D. & Van, L. M., Sept 2009, In: European Journal of Cancer Supplements. 7, 2, p. 81-81Research output: Contribution to journal › Conference proceedings published in a journal › peer-review
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A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites
Uren, A. G., Mikkers, H., Kool, J., van, D. W. L., Lund, A. H., Wilson, C. H., Rance, R., Jonkers, J., van, L. M., Berns, A. & Adams, D. J., May 2009, In: Nature Protocols. 4, 5, p. 789-798Research output: Contribution to journal › Article › peer-review
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Jump-starting cancer gene discovery
Uren, A. & Berns, A., Mar 2009, In: Nature Biotechnology. 27, 3, p. 251-252Research output: Contribution to journal › Article › peer-review
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2008
Instant conditional transgenesis in the mouse hematopoietic compartment
Csikós, T., Reijmers, R. M., Uren, A. G., Spaargaren, M. & Pals, S. T., Dec 2008, In: Journal of Immunological Methods. 339, 2, p. 259-263Research output: Contribution to journal › Article › peer-review
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Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks
Uren, A. G., Kool, J., Matentzoglu, K., de, R. J., Mattison, J., van, U. M., Lagcher, W., Sie, D., Tanger, E., Cox, T., Reinders, M., Hubbard, T. J., Rogers, J., Jonkers, J., Wessels, L., Adams, D. J., van, L. M. & Berns, A., May 2008, In: Cell. 133, 4, p. 727-741Research output: Contribution to journal › Article › peer-review
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2007
Co-occurrence analysis of insertional mutagenesis data reveals cooperating oncogenes
de, R. J., Kool, J., Uren, A., Bot, J., Wessels, L. & Reinders, M., 1 Jul 2007, In: Bioinformatics. 23, 13, p. i133-i141Research output: Contribution to journal › Article › peer-review
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2006
Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens
de, R. J., Uren, A., Kool, J., Reinders, M. & Wessels, L., 2006, In: PLoS Computational Biology. 2, 12, p. e166-e166Research output: Contribution to journal › Article › peer-review
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2005
Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens
de, R. J., Uren, A., Kool, J., Reinders, M. & Wessels, L., 2005.Research output: Working paper › Preprint
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Retroviral insertional mutagenesis: past, present and future
Uren, A. G., Kool, J., Berns, A. & van, L. M., 21 Nov 2005, In: Oncogene. 24, 52, p. 7656-7672Research output: Contribution to journal › Article › peer-review
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2000
Identification of Paracaspases and Metacaspases
Uren, A. G., O'Rourke, K., Aravind, L., Pisabarro, M. T., Seshagiri, S., Koonin, E. V. & Dixit, V. M., Oct 2000, In: Molecular Cell. 6, 4, p. 961-967Research output: Contribution to journal › Article › peer-review
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Identification of Paracaspases and Metacaspases Two Ancient Families of Caspase-like Proteins, One of which Plays a Key Role in MALT Lymphoma
Uren, A., Oct 2000, In: Molecular Cell. 6, 4, p. 961-967Research output: Contribution to journal › Article › peer-review
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Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
Uren, A. G., Wong, L., Pakusch, M., Fowler, K. J., Burrows, F. J., Vaux, D. L. & Choo, K. H. A., Nov 2000, In: Current Biology. 10, 21, p. 1319-1328Research output: Contribution to journal › Article › peer-review
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The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone
Speliotes, E. K., Uren, A., Vaux, D. & Horvitz, H. R., Aug 2000, In: Molecular Cell. 6, 2, p. 211-223Research output: Contribution to journal › Article › peer-review
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1999
Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division
Uren, A. G., Beilharz, T., O’Connell, M., Bugg, S. J., van, D. R., Vaux, D. L. & Lithgow, T., 31 Aug 1999, In: Proceedings of the National Academy of Sciences. 96, 18, p. 10170-10175Research output: Contribution to journal › Article › peer-review
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1998
Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells
Hawkins, C. J., Ekert, P. G., Uren, A. G., Holmgreen, S. P. & Vaux, D. L., Jul 1998, In: Cell Death & Differentiation. 5, 7, p. 569-576Research output: Contribution to journal › Article › peer-review
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Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts
Uren, A. G., Coulson, E. J. & Vaux, D. L., May 1998, In: Trends in Biochemical Sciences. 23, 5, p. 159-162Research output: Contribution to journal › Article › peer-review
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1997
Motor neurone disease and the life of motor neurones
Vaux, D. L., Hawkins, C. J., Uren, A. G. & Ekert, P. G., 20 Jan 1997, In: Medical Journal of Australia. 166, 2, p. 109, author reply 109-10Research output: Contribution to journal › Article › peer-review
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Viral Inhibitors of Apoptosis
Uren, A. G. & Vaux, D. L., 1997, Vitamins & Hormones. Vol. 0. p. 175-193Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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1996
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.
Uren, A. G., Pakusch, M., Hawkins, C. J., Puls, K. L. & Vaux, D. L., 14 May 1996, In: Proceedings of the National Academy of Sciences. 93, 10, p. 4974-4978Research output: Contribution to journal › Article › peer-review
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Inhibition of interleukin 1β-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP
Hawkins, C. J., Uren, A. G., Häcker, G., Medcalf, R. L. & Vaux, D. L., 26 Nov 1996, In: Proceedings of the National Academy of Sciences. 93, 24, p. 13786-13790Research output: Contribution to journal › Article › peer-review
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Molecular and clinical aspects of apoptosis
Uren, A. G. & Vaux, D. L., Jan 1996, In: Pharmacology & Therapeutics. 72, 1, p. 37-50Research output: Contribution to journal › Article › peer-review
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TRAF protiens and meprins share a conserved domain
Uren, A. & Vaux, D., Jul 1996, In: Trends in Biochemical Sciences. 21, 7, p. 244-245Research output: Contribution to journal › Article › peer-review