Research Group Leads: Dr Tracey Madgett and Dr Lynn McCallum

The Blood Diagnostics Research Group is dedicated to completing research that is driven by the desire to translate findings into clinical practice. 

We have developed blood group genotyping approaches that investigate the complete genes of the major blood group systems. In this we have identified multiple blood group alleles, critical for the development of software tools to genotype patients and donors using current next generation sequencing platforms. We have also investigated novel approaches to non-invasive testing of Down syndrome, and to understand the pathology of this condition. Other projects include the development of recombinant Rh antigens and understanding the mechanisms of red cell turnover, especially involving red cell CD47. Currently we are working on understanding the mechanisms of cryopreservation of red blood cells.